Synergistic effect of antimicrobial activity between Centella asiatica and Curcuma domestica loir towards Gram-positive bacteria
Aims: The rising threat of antimicrobial resistance (AMR) has become one of the most critical global concerns. The resistance properties exhibited by these microorganisms cause the current antibacterial agents to become ineffective. The aim of this study was to assess the synergistic effect of eth...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Malaysian Society for Microbiology
2025
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| Subjects: | |
| Online Access: | https://umpir.ump.edu.my/id/eprint/46750/1/MJM2-24-0727-%20EV%20Formatted-Color%20Ready.pdf https://umpir.ump.edu.my/id/eprint/46750/ http://dx.doi.org/10.21161/mjm.240727 |
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| Summary: | Aims:
The rising threat of antimicrobial resistance (AMR) has become one of the most critical global concerns. The resistance properties exhibited by these microorganisms cause the current antibacterial agents to become ineffective. The aim of this study was to assess the synergistic effect of ethanolic extracts of Centella asiatica and Curcuma domestica loir (CDL) leaves against Gram-positive bacteria.
Methodology and results:
Three different concentration ratios of the synergised leaf extracts were used with 1:1 (C. asiatica: C. domestica) ratios, 2:1 (C. asiatica: C. domestica) ratios and 1:2 (C. asiatica: C. domestica) ratios. The ratio of 2:1 (C. asiatica: C. domestica) extracts showed the highest inhibition zone with an average of 34.7 mm, followed by 1:1 (C. asiatica: C. domestica) with an average value of the inhibition zone of 27 mm and 1:2 (C. asiatica: C. domestica) with an average value of the inhibition zone of 23.3 mm.
Conclusion, significance and impact of study:
The combination of both plant extracts has demonstrated a synergistic effect, enhancing antimicrobial activity and offering a promising opportunity for developing natural products to combat antimicrobial resistance. |
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