Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy
Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8)....
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Springer Nature
2025
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/45377/1/Original%20article%20-%20HA-ZIF-8.pdf http://umpir.ump.edu.my/id/eprint/45377/ https://doi.org/10.1007/s11051-025-06412-0 |
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| Summary: | Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC50 = 21.5 ± 3.8 µg mL−1), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells. |
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