Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
Two Malaysian plants of Kopsia arborea Blume (family: Apocynaceae) of different geographical locations, one of which was collected in Petaling Jaya, Selangor (Sample A), and the other in Penang Island (Sample B), were investigated for their alkaloidal composition. A total of 60 alkaloids (1−60) were...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
2024
|
| Subjects: | |
| Online Access: | http://studentsrepo.um.edu.my/15692/2/Wong_Soon_Kit.pdf http://studentsrepo.um.edu.my/15692/1/Wong_Soon_Kit.pdf http://studentsrepo.um.edu.my/15692/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1831436680831172608 |
|---|---|
| author | Wong , Soon Kit |
| author_facet | Wong , Soon Kit |
| author_sort | Wong , Soon Kit |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Student Repository |
| continent | Asia |
| country | Malaysia |
| description | Two Malaysian plants of Kopsia arborea Blume (family: Apocynaceae) of different geographical locations, one of which was collected in Petaling Jaya, Selangor (Sample A), and the other in Penang Island (Sample B), were investigated for their alkaloidal composition. A total of 60 alkaloids (1−60) were isolated and characterized from the stem-bark extracts of these sources, of which eight are new alkaloids. Of these, arbophyllidine (1) and arboduridine (2) are distinguished by incorporation of novel molecular skeletons, and arbophyllinines A (6) and B (7) are two corynanthean alkaloids incorporating a substituted tetrahydrofuranone ring. The aspidofractinine-aspidofractinine bisindole alkaloid, arbolodinine A (58), is notable for being a rare instance of a bisindole alkaloid branched from an iminium ion, while arbolodinines B (59) and C (60) represent the first examples of strychnan-aspidofractinine and strychnan-kopsine bisindole alkaloids, respectively. Among the new alkaloids, arbophyllidine (1) showed pronounced in vitro growth inhibitory activity against HT-29 human cancer cell line (IC50: 6.2 M), and arbolodinine B (59) displayed strong cytotoxicity against KB, vincristine-resistant KB, PC-3, HCT 116, HT-29, MDA-MB-231, MCF7, and A549 cells (IC50: 1.3−9.6 M). The alkaloid compositions of the two plants are summarized in Table 2.1.
|
| format | Thesis |
| id | my.um.stud-15692 |
| institution | Universiti Malaya |
| publishDate | 2024 |
| record_format | eprints |
| spelling | my.um.stud-156922025-01-02T00:21:29Z Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit Wong , Soon Kit Q Science (General) QD Chemistry Two Malaysian plants of Kopsia arborea Blume (family: Apocynaceae) of different geographical locations, one of which was collected in Petaling Jaya, Selangor (Sample A), and the other in Penang Island (Sample B), were investigated for their alkaloidal composition. A total of 60 alkaloids (1−60) were isolated and characterized from the stem-bark extracts of these sources, of which eight are new alkaloids. Of these, arbophyllidine (1) and arboduridine (2) are distinguished by incorporation of novel molecular skeletons, and arbophyllinines A (6) and B (7) are two corynanthean alkaloids incorporating a substituted tetrahydrofuranone ring. The aspidofractinine-aspidofractinine bisindole alkaloid, arbolodinine A (58), is notable for being a rare instance of a bisindole alkaloid branched from an iminium ion, while arbolodinines B (59) and C (60) represent the first examples of strychnan-aspidofractinine and strychnan-kopsine bisindole alkaloids, respectively. Among the new alkaloids, arbophyllidine (1) showed pronounced in vitro growth inhibitory activity against HT-29 human cancer cell line (IC50: 6.2 M), and arbolodinine B (59) displayed strong cytotoxicity against KB, vincristine-resistant KB, PC-3, HCT 116, HT-29, MDA-MB-231, MCF7, and A549 cells (IC50: 1.3−9.6 M). The alkaloid compositions of the two plants are summarized in Table 2.1. 2024-08 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/15692/2/Wong_Soon_Kit.pdf application/pdf http://studentsrepo.um.edu.my/15692/1/Wong_Soon_Kit.pdf Wong , Soon Kit (2024) Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit. PhD thesis, Universiti Malaya. http://studentsrepo.um.edu.my/15692/ |
| spellingShingle | Q Science (General) QD Chemistry Wong , Soon Kit Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit |
| title | Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
|
| title_full | Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
|
| title_fullStr | Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
|
| title_full_unstemmed | Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
|
| title_short | Further phytochemical and cytotoxicity studies of the indole alkaloids of Kopsia arborea STEM-BARK / Wong Soon Kit
|
| title_sort | further phytochemical and cytotoxicity studies of the indole alkaloids of kopsia arborea stem-bark / wong soon kit |
| topic | Q Science (General) QD Chemistry |
| url | http://studentsrepo.um.edu.my/15692/2/Wong_Soon_Kit.pdf http://studentsrepo.um.edu.my/15692/1/Wong_Soon_Kit.pdf http://studentsrepo.um.edu.my/15692/ |
| url_provider | http://studentsrepo.um.edu.my/ |