Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. T...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/9349/1/Theoretical_development_and_critical_analysis_of_burst_frequency.pdf http://eprints.um.edu.my/9349/ http://www.scopus.com/inward/record.url?eid=2-s2.0-84880347141&partnerID=40&md5=231f057d68056ae7807b5683bc4d86d1 http://link.springer.com/article/10.1007/s11517-012-1020-7 http://www.ncbi.nlm.nih.gov/pubmed/23292292 |
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| Summary: | This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure. © 2013 International Federation for Medical and Biological Engineering. |
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