The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid
The pseudo-first-order rate constants (k(obs)) for the intramolecular carboxylic group-assisted cleavage of N-(4'-nitrophenyl)phthalamic acid (1) show nonlinear decrease of similar to 17-fold and similar to 117-fold with the increase in the respective contents of CH3CN (10-80% v/v) and 1,4-diox...
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2007
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| author | Ariffin, Azhar Khan, M.N. Ahmad, W.H.W. |
| author_facet | Ariffin, Azhar Khan, M.N. Ahmad, W.H.W. |
| author_sort | Ariffin, Azhar |
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| country | Malaysia |
| description | The pseudo-first-order rate constants (k(obs)) for the intramolecular carboxylic group-assisted cleavage of N-(4'-nitrophenyl)phthalamic acid (1) show nonlinear decrease of similar to 17-fold and similar to 117-fold with the increase in the respective contents of CH3CN (10-80% v/v) and 1,4-dioxan (9.5-79.4% v/v) in mixed aqueous solvents. The fraction of N-cyclization of 1 leading to the formation of N-(4'-nitrophenyl)phthalimide, 2, remains almost zero at <= 40% v/v CH3CN while it increases from 0.06 to 0.49 with increase in CH3CN content (50-80% v/v) at 1.0 x 10(-3) M HCl. However, the observed data reveal an almost absence of N-cyclization within 1,4-dioxan content range 10-80% v/v. |
| format | Article |
| id | my.um.eprints-8049 |
| institution | Universiti Malaya |
| publishDate | 2007 |
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| spelling | my.um.eprints-80492019-08-27T04:53:25Z http://eprints.um.edu.my/8049/ The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid Ariffin, Azhar Khan, M.N. Ahmad, W.H.W. QD Chemistry The pseudo-first-order rate constants (k(obs)) for the intramolecular carboxylic group-assisted cleavage of N-(4'-nitrophenyl)phthalamic acid (1) show nonlinear decrease of similar to 17-fold and similar to 117-fold with the increase in the respective contents of CH3CN (10-80% v/v) and 1,4-dioxan (9.5-79.4% v/v) in mixed aqueous solvents. The fraction of N-cyclization of 1 leading to the formation of N-(4'-nitrophenyl)phthalimide, 2, remains almost zero at <= 40% v/v CH3CN while it increases from 0.06 to 0.49 with increase in CH3CN content (50-80% v/v) at 1.0 x 10(-3) M HCl. However, the observed data reveal an almost absence of N-cyclization within 1,4-dioxan content range 10-80% v/v. 2007 Article PeerReviewed Ariffin, Azhar and Khan, M.N. and Ahmad, W.H.W. (2007) The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid. Indian Journal of Chemistry Section a-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry, 46 (3). pp. 416-461. ISSN 0376-4710, http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=11&SID=X15kP6BDACOiH3JKAnO&page=1&doc=1 |
| spellingShingle | QD Chemistry Ariffin, Azhar Khan, M.N. Ahmad, W.H.W. The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title | The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title_full | The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title_fullStr | The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title_full_unstemmed | The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title_short | The Kinetic Study On The Effects Of Mixed Aqueous-Organic Solvents On The Rate Of O- And N- Cyclisation Of N-(4 '-Nitrophenyl)Phthalamic Acid |
| title_sort | kinetic study on the effects of mixed aqueous-organic solvents on the rate of o- and n- cyclisation of n-(4 '-nitrophenyl)phthalamic acid |
| topic | QD Chemistry |
| url | http://eprints.um.edu.my/8049/ http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=11&SID=X15kP6BDACOiH3JKAnO&page=1&doc=1 |
| url_provider | http://eprints.um.edu.my/ |