Kinetics and mechanism of intramolecular Carboxylic Acid participation in the hydrolysis of N-Methoxyphthalamic Acid
The rate of formation and disappearance of phthalic anhydride (PAn) intermediate in the aqueous cleavage of N-methoxyphthalamic acid (NMPA) under acidic pH was studied spectrophotometrically in mixed CH3CN-H2O solvents. The rate of formation of PAn from NMPA is almost independent of the change in ac...
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| Main Authors: | , |
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| Format: | Article |
| Language: | en |
| Published: |
2003
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/8040/1/Khan-2003-Kinetics_and_mechani.pdf http://eprints.um.edu.my/8040/ http://pubs.rsc.org/en/content/articlepdf/2003/ob/b300662j |
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| Summary: | The rate of formation and disappearance of phthalic anhydride (PAn) intermediate in the aqueous cleavage of N-methoxyphthalamic acid (NMPA) under acidic pH was studied spectrophotometrically in mixed CH3CN-H2O solvents. The rate of formation of PAn from NMPA is almost independent of the change in acetonitrile content from 20 to 70% v/v in mixed aqueous solvents. The rate constants for the formation of PAn from NMPA are similar to10-fold smaller than the corresponding rate constants for the formation of PAn from o-carboxybenzohydroxamic acid (OCBA). These observations are ascribed to the consequence of the occurrence of slightly different mechanisms in these reactions. |
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