Chronic neutrophilic leukaemia.
Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Stamford Publishing Pte Ltd / Singapore Medical Association
2007
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/624/ http://www.ncbi.nlm.nih.gov/pubmed/17342275 |
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| Summary: | Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. He subsequently passed away with bronchopneumonia. |
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