The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia
Earlier studies in the 1990s indicate that human immunodeficiency virus type 1 (HIV-1) subtype B has been the predominant subtype among injecting drug users (IDUs) in Malaysia. More recent studies performed between 2003 and 2004, however, show a high prevalence of unique CRF01AE/B intersubtype recom...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2005
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/4573/1/The_evolving_molecular_epidemiology_of_HIV_type_1_among_injecting_drug_users_%28IDUs%29_in_Malaysia.pdf http://eprints.um.edu.my/4573/ |
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| Summary: | Earlier studies in the 1990s indicate that human immunodeficiency virus type 1 (HIV-1) subtype B has been the predominant subtype among injecting drug users (IDUs) in Malaysia. More recent studies performed between 2003 and 2004, however, show a high prevalence of unique CRF01AE/B intersubtype recombinants among IDUs. To determine the subtype distribution among IDUs in Kuala Lumpur prior to the emergence of CRF01AE/B intersubtype recombinants, the gag-pol or the reverse transcriptase gene was sequenced from IDUs who were diagnosed as HIV positive between 1993 and 2002. Subtype B was present at 50.0 followed by CRF01AE/B recombinant at 41.7, with more CRF01AE/B recombinants detected between 2000 and 2002. All CRF01AE/B recombinants shared similar recombination patterns. Interestingly, we found that this potential new candidate of circulating recombinant form (CRF) could have emerged as early as the mid-1990s. The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01AE/B intersubtype recombinants among IDUs in Kuala Lumpur. |
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