Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy
Purpose In this study, we aimed to investigate the possible association between SLC2A126177A/Gpolymorphism and diabetic retinopathy (DR) in Malaysianpatients with type 2 diabetes. Methods Genomic DNA was extracted from 211 Malaysian type 2 diabeticpatients (100 without retinopathy DNR, 111 with reti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3831/1/Investigation_of_SLC2A1_26177AG_gene_polymorphism_via_high_resolution_melting_curve_analysis_on_Malaysian_patients_with_diabetic.pdf http://eprints.um.edu.my/3831/ |
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| Summary: | Purpose In this study, we aimed to investigate the possible association between SLC2A126177A/Gpolymorphism and diabetic retinopathy (DR) in Malaysianpatients with type 2 diabetes. Methods Genomic DNA was extracted from 211 Malaysian type 2 diabeticpatients (100 without retinopathy DNR, 111 with retinopathy) and 165 healthy controls. A highresolutionmelting assay developed in this study was used to detect SLC2A126177A/Gpolymorphism followed by statistical analysis. Results A statistically significant difference in 26177 G minor allele frequency between healthy controls (19.7 %) and total patient group (26.1 %) (p < 0.05, Odd ratio = 1.437, 95% Confidence interval = 1.015�2.035) as well as between healthy controls (19.7 %) and DNR patients (27.5%) (p < 0.05, Odd ratio = 1.546, 95% Confidence interval = 1.024�2.336) was shown in this study. However, when compared between DR and DNR patients, there was no significant difference (p > 0.05). Conclusions This is the first study which shows that SLC2A1 26177G allele is associated with type 2 diabetes in Malaysian population but not with DR. |
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