Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats
The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inh...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3702/1/Protective_effects_of_Mucuna_pruriens_seed_extract_pretreatment_against_cardiovascular_and_respiratory_depressant_effects_of_Calloselasma_rhodostoma_%28Malayan_pit_viper%29.pdf http://eprints.um.edu.my/3702/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1831446632004059136 |
|---|---|
| author | Fung, S.Y. Tan, N.H. Sim, S.M. |
| author_facet | Fung, S.Y. Tan, N.H. Sim, S.M. |
| author_sort | Fung, S.Y. |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated the venom-induced cardio-respiratory depressant effects (p<0.05). The protection effects may have an immunological mechanism, as indicated by the presence of several proteins in the venom that are immunoreactive against anti-MPE. However, we cannot rule out the possibility that the pretreatment may exert a direct, non-immunological protective action against the venom. |
| format | Article |
| id | my.um.eprints-3702 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2010 |
| record_format | eprints |
| spelling | my.um.eprints-37022012-09-27T03:18:01Z http://eprints.um.edu.my/3702/ Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats Fung, S.Y. Tan, N.H. Sim, S.M. R Medicine The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated the venom-induced cardio-respiratory depressant effects (p<0.05). The protection effects may have an immunological mechanism, as indicated by the presence of several proteins in the venom that are immunoreactive against anti-MPE. However, we cannot rule out the possibility that the pretreatment may exert a direct, non-immunological protective action against the venom. 2010 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3702/1/Protective_effects_of_Mucuna_pruriens_seed_extract_pretreatment_against_cardiovascular_and_respiratory_depressant_effects_of_Calloselasma_rhodostoma_%28Malayan_pit_viper%29.pdf Fung, S.Y. and Tan, N.H. and Sim, S.M. (2010) Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats. Tropical Biomedicine, 27 (3). pp. 366-372. ISSN 0127-5720, |
| spellingShingle | R Medicine Fung, S.Y. Tan, N.H. Sim, S.M. Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title | Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title_full | Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title_fullStr | Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title_full_unstemmed | Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title_short | Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats |
| title_sort | protective effects of mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of calloselasma rhodostoma (malayan pit viper) venom in rats |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3702/1/Protective_effects_of_Mucuna_pruriens_seed_extract_pretreatment_against_cardiovascular_and_respiratory_depressant_effects_of_Calloselasma_rhodostoma_%28Malayan_pit_viper%29.pdf http://eprints.um.edu.my/3702/ |
| url_provider | http://eprints.um.edu.my/ |