Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures
This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and phospholipase activities were detected in 93.7% and 73.3...
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| Language: | en |
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Oxford University Press
2011
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| Online Access: | http://eprints.um.edu.my/3549/1/Proteinase%2Cphospholipase%2Cbiofilm_forming_abilities_and_antifungal_susceptibilities_of_Malaysian_Candida_isolates_from_blood_culture.pdf http://eprints.um.edu.my/3549/ https://doi.org/10.3109/13693786.2010.551424 |
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| author | Tay, Sun Tee Abidin, Ira Azzura Zainal Hassan, Hamimah Ng, Kee Peng |
| author_facet | Tay, Sun Tee Abidin, Ira Azzura Zainal Hassan, Hamimah Ng, Kee Peng |
| author_sort | Tay, Sun Tee |
| building | UM Library |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and phospholipase activities were detected in 93.7% and 73.3%, respectively, of 15 Candida albicans isolates. Amongst the 26 non-C. albicans Candida isolates, proteinase and phospholipase activities were detected in 88.5% and 7.7% of the isolates, respectively. There was no significant difference in the expression levels of proteinase amongst the Candida isolates studied (P = 0.272), but the phospholipase activity of C. albicans was significantly higher than that of the non-C. albicans Candida isolates (P = 0.003). There was no significant difference in the biofilm forming abilities of C. albicans and non-C. albicans Candida isolates on the polystyrene microtiter wells (P = 0.379). In addition, the findings of this study demonstrate increased resistance of Candida isolates in biofilms to amphotericin and fluconazole, as compared to their planktonic counterparts. |
| format | Article |
| id | my.um.eprints-3549 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2011 |
| publisher | Oxford University Press |
| record_format | eprints |
| spelling | my.um.eprints-35492019-11-18T08:01:23Z http://eprints.um.edu.my/3549/ Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures Tay, Sun Tee Abidin, Ira Azzura Zainal Hassan, Hamimah Ng, Kee Peng R Medicine This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and phospholipase activities were detected in 93.7% and 73.3%, respectively, of 15 Candida albicans isolates. Amongst the 26 non-C. albicans Candida isolates, proteinase and phospholipase activities were detected in 88.5% and 7.7% of the isolates, respectively. There was no significant difference in the expression levels of proteinase amongst the Candida isolates studied (P = 0.272), but the phospholipase activity of C. albicans was significantly higher than that of the non-C. albicans Candida isolates (P = 0.003). There was no significant difference in the biofilm forming abilities of C. albicans and non-C. albicans Candida isolates on the polystyrene microtiter wells (P = 0.379). In addition, the findings of this study demonstrate increased resistance of Candida isolates in biofilms to amphotericin and fluconazole, as compared to their planktonic counterparts. Oxford University Press 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3549/1/Proteinase%2Cphospholipase%2Cbiofilm_forming_abilities_and_antifungal_susceptibilities_of_Malaysian_Candida_isolates_from_blood_culture.pdf Tay, Sun Tee and Abidin, Ira Azzura Zainal and Hassan, Hamimah and Ng, Kee Peng (2011) Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures. Medical Mycology, 49 (5). pp. 556-560. ISSN 1369-3786, DOI https://doi.org/10.3109/13693786.2010.551424 <https://doi.org/10.3109/13693786.2010.551424>. https://doi.org/10.3109/13693786.2010.551424 doi:10.3109/13693786.2010.551424 |
| spellingShingle | R Medicine Tay, Sun Tee Abidin, Ira Azzura Zainal Hassan, Hamimah Ng, Kee Peng Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title | Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title_full | Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title_fullStr | Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title_full_unstemmed | Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title_short | Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures |
| title_sort | proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of malaysian candida isolates from blood cultures |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3549/1/Proteinase%2Cphospholipase%2Cbiofilm_forming_abilities_and_antifungal_susceptibilities_of_Malaysian_Candida_isolates_from_blood_culture.pdf http://eprints.um.edu.my/3549/ https://doi.org/10.3109/13693786.2010.551424 |
| url_provider | http://eprints.um.edu.my/ |