Silencing quorum sensing through extracts of Melicope lunu-ankenda
Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden sa...
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| Format: | Article |
| Language: | en |
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MDPI
2012
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| Online Access: | http://eprints.um.edu.my/3321/1/7.pdf http://eprints.um.edu.my/3321/ https://doi.org/10.3390/s120404339 |
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| author | Tan, L.Y. Yin, W.F. Chan, Kok Gan |
| author_facet | Tan, L.Y. Yin, W.F. Chan, Kok Gan |
| author_sort | Tan, L.Y. |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds. |
| format | Article |
| id | my.um.eprints-3321 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | eprints |
| spelling | my.um.eprints-33212018-10-30T01:54:51Z http://eprints.um.edu.my/3321/ Silencing quorum sensing through extracts of Melicope lunu-ankenda Tan, L.Y. Yin, W.F. Chan, Kok Gan Q Science (General) R Medicine Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds. MDPI 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3321/1/7.pdf Tan, L.Y. and Yin, W.F. and Chan, Kok Gan (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors, 12 (4). pp. 4339-4351. ISSN 1424-8220, DOI https://doi.org/10.3390/s120404339 <https://doi.org/10.3390/s120404339>. https://doi.org/10.3390/s120404339 doi:10.3390/s120404339 |
| spellingShingle | Q Science (General) R Medicine Tan, L.Y. Yin, W.F. Chan, Kok Gan Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title | Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title_full | Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title_fullStr | Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title_full_unstemmed | Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title_short | Silencing quorum sensing through extracts of Melicope lunu-ankenda |
| title_sort | silencing quorum sensing through extracts of melicope lunu-ankenda |
| topic | Q Science (General) R Medicine |
| url | http://eprints.um.edu.my/3321/1/7.pdf http://eprints.um.edu.my/3321/ https://doi.org/10.3390/s120404339 |
| url_provider | http://eprints.um.edu.my/ |