Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects
Elevated activity of plasminogen activator inhibitor-1 (PAI-1) and decreased tissue plasminogen activator (tPA) activity are considered to be important risk factors for type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). The aim of this study was to investigate the association of the PAI-...
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2012
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| Online Access: | http://eprints.um.edu.my/3155/ http://www.ncbi.nlm.nih.gov/pubmed/22577291 |
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| author | Al-Hamodi, Z. Saif-Ali, R. Ismail, I.S. Ahmed, K.A. Muniandy, S. |
| author_facet | Al-Hamodi, Z. Saif-Ali, R. Ismail, I.S. Ahmed, K.A. Muniandy, S. |
| author_sort | Al-Hamodi, Z. |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Elevated activity of plasminogen activator inhibitor-1 (PAI-1) and decreased tissue plasminogen activator (tPA) activity are considered to be important risk factors for type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). The aim of this study was to investigate the association of the PAI-1 4G/5G and tPA Alu-repeat I/D polymorphisms with T2DM in Malaysian subjects. Serum insulin, coronary risk panel, plasma glucose, and PAI-1 4G/5G and tPA Alu-repeat I/D polymorphisms were studied in 303 T2DM subjects (227 with MetS and 76 without MetS) and 131 normal subjects without diabetes and MetS. Statistical analysis showed that the dominant and additive models of PAI-1 4G/5G polymorphism showed a weak association with T2DM without MetS (OR = 2.35, P = 0.045; OR = 1.67, P = 0.058). On the other hand, the recessive model of the tPA Alu-repeat I/D polymorphism showed an association with T2DM with MetS (OR = 3.32, P = 0.013) whereas the dominant and additive models of the tPA Alu-repeat I/D polymorphism were not associated with T2DM either with or without MetS. |
| format | Article |
| id | my.um.eprints-3155 |
| institution | Universiti Malaya |
| publishDate | 2012 |
| record_format | eprints |
| spelling | my.um.eprints-31552014-12-19T03:30:36Z http://eprints.um.edu.my/3155/ Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects Al-Hamodi, Z. Saif-Ali, R. Ismail, I.S. Ahmed, K.A. Muniandy, S. R Medicine Elevated activity of plasminogen activator inhibitor-1 (PAI-1) and decreased tissue plasminogen activator (tPA) activity are considered to be important risk factors for type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). The aim of this study was to investigate the association of the PAI-1 4G/5G and tPA Alu-repeat I/D polymorphisms with T2DM in Malaysian subjects. Serum insulin, coronary risk panel, plasma glucose, and PAI-1 4G/5G and tPA Alu-repeat I/D polymorphisms were studied in 303 T2DM subjects (227 with MetS and 76 without MetS) and 131 normal subjects without diabetes and MetS. Statistical analysis showed that the dominant and additive models of PAI-1 4G/5G polymorphism showed a weak association with T2DM without MetS (OR = 2.35, P = 0.045; OR = 1.67, P = 0.058). On the other hand, the recessive model of the tPA Alu-repeat I/D polymorphism showed an association with T2DM with MetS (OR = 3.32, P = 0.013) whereas the dominant and additive models of the tPA Alu-repeat I/D polymorphism were not associated with T2DM either with or without MetS. 2012 Article PeerReviewed Al-Hamodi, Z. and Saif-Ali, R. and Ismail, I.S. and Ahmed, K.A. and Muniandy, S. (2012) Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects. Journal of Biomedicine and Biotechnology. ISSN 1110-7243, DOI PMID: 22577291. http://www.ncbi.nlm.nih.gov/pubmed/22577291 PMID: 22577291 |
| spellingShingle | R Medicine Al-Hamodi, Z. Saif-Ali, R. Ismail, I.S. Ahmed, K.A. Muniandy, S. Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title | Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title_full | Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title_fullStr | Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title_full_unstemmed | Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title_short | Effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| title_sort | effect of plasminogen activator inhibitor-1 and tissue plasminogen activator polymorphisms on susceptibility to type 2 diabetes in malaysian subjects |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3155/ http://www.ncbi.nlm.nih.gov/pubmed/22577291 |
| url_provider | http://eprints.um.edu.my/ |