Oscillations and waves of intracellular CA2+ in cardiac-muscle-cells
When cardiac muscle cells become overloaded with Ca2+, spontaneous releases of Ca2+ from the sarcoplasmic reticulum can occur. Such spontaneous releases normally originate within a localized region of the cell and propagate as a wave throughout the cell. The amplitude and frequency of these Ca2+ rel...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | en |
| Published: |
Elsevier
1995
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3034/1/Oscillations_and_waves_of_intracellular_%5BCa2%2B%5D_in_cardiac_muscle_cells.pdf http://eprints.um.edu.my/3034/ https://doi.org/10.1016/0960-0779(93)E0036-B |
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| Summary: | When cardiac muscle cells become overloaded with Ca2+, spontaneous releases of Ca2+ from the sarcoplasmic reticulum can occur. Such spontaneous releases normally originate within a localized region of the cell and propagate as a wave throughout the cell. The amplitude and frequency of these Ca2+ releases increase with the degree of Ca2+ loading of the cell, and are abolished by interventions which inhibit sarcoplasmic reticulum function. It is still not clear whether these releases are triggered by a rise in the Ca2+ in the lumen of the sarcoplasmic reticulum or by a rise in cytoplasmic Ca2+. Such releases may, however, by activating inward currents, depolarize the cell membrane and thus be arrhythmogenic; they may also, by decreasing the amount of Ca2+ within the sarcoplasmic reticulum, decrease the strength of a stimulated contraction. |
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