Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity
A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/2521/1/malabaricone_c.pdf http://eprints.um.edu.my/2521/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1831446422873964544 |
|---|---|
| author | Chong, Y.M. Yin, W.F. Ho, C.Y. Mustafa, Mohd Rais Hadi, A.H.A. Awang, K. Narrima, P. Koh, C.L. |
| author_facet | Chong, Y.M. Yin, W.F. Ho, C.Y. Mustafa, Mohd Rais Hadi, A.H.A. Awang, K. Narrima, P. Koh, C.L. |
| author_sort | Chong, Y.M. |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | A methanol-soluble extract of the bark of Myristica
cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further |
| format | Article |
| id | my.um.eprints-2521 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2011 |
| record_format | eprints |
| spelling | my.um.eprints-25212019-12-18T06:37:07Z http://eprints.um.edu.my/2521/ Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity Chong, Y.M. Yin, W.F. Ho, C.Y. Mustafa, Mohd Rais Hadi, A.H.A. Awang, K. Narrima, P. Koh, C.L. Q Science (General) QD Chemistry RM Therapeutics. Pharmacology A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further 2011-09-12 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2521/1/malabaricone_c.pdf Chong, Y.M. and Yin, W.F. and Ho, C.Y. and Mustafa, Mohd Rais and Hadi, A.H.A. and Awang, K. and Narrima, P. and Koh, C.L. (2011) Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity. Journal of Natural Products, 74 (10). pp. 2261-2264. |
| spellingShingle | Q Science (General) QD Chemistry RM Therapeutics. Pharmacology Chong, Y.M. Yin, W.F. Ho, C.Y. Mustafa, Mohd Rais Hadi, A.H.A. Awang, K. Narrima, P. Koh, C.L. Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title | Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title_full | Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title_fullStr | Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title_full_unstemmed | Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title_short | Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity |
| title_sort | malabaricone c from myristica cinnamomea exhibits anti-quorum sensing activity |
| topic | Q Science (General) QD Chemistry RM Therapeutics. Pharmacology |
| url | http://eprints.um.edu.my/2521/1/malabaricone_c.pdf http://eprints.um.edu.my/2521/ |
| url_provider | http://eprints.um.edu.my/ |