Malabaricone C from Myristica Cinnamomea exhibits Anti-Quorum sensing activity
A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
2011
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/2521/1/malabaricone_c.pdf http://eprints.um.edu.my/2521/ |
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| Summary: | A methanol-soluble extract of the bark of Myristica
cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further |
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