Growth hormone deficiency in adults
Adults with Growth hormone (GH) deficiency is now being recognised to display many distinct clinical, metabolic and psychological abnormalities. It has been demonstrated that GI-I deficient (GHD) adults display features of multiple insulin resistant syndrome (MIRS) which predispose the GHD adults to...
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| Format: | Article |
| Language: | en |
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Faculty of Medicine, University of Malaya
1999
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| Online Access: | http://eprints.um.edu.my/24708/1/document%20%282%29.pdf http://eprints.um.edu.my/24708/ https://jummec.um.edu.my/article/view/4438 |
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| _version_ | 1831507913723609088 |
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| author | Hew, Fen Lee Alford, Frank |
| author_facet | Hew, Fen Lee Alford, Frank |
| author_sort | Hew, Fen Lee |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Adults with Growth hormone (GH) deficiency is now being recognised to display many distinct clinical, metabolic and psychological abnormalities. It has been demonstrated that GI-I deficient (GHD) adults display features of multiple insulin resistant syndrome (MIRS) which predispose the GHD adults to increased cardiovascular morbidity and mortality. These features include central obesity, insulin resistance and glucose intolerance, hypertension, dyslipidaemia that includes a reduced level of high density lipoprotein cholesterol, an elevated triglyceride level and small low density lipoprotein cholesterol size. Furthermore, GHD adults are found to have a lower bone mass and a reduced sense of well-being. Replacement of GH in these GHD adults has brought about a major improvement in psychological well-being and central obesity. The improvement of some of the lipid abnormalities is however more modest. Insulin resistance, the corner stone of MIRS, is however not altered by GH replacement. Long term data is as yet unavailable to assess if GH replacement reduces cardiovascular mortality and morbidity in these subjects. |
| format | Article |
| id | my.um.eprints-24708 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 1999 |
| publisher | Faculty of Medicine, University of Malaya |
| record_format | eprints |
| spelling | my.um.eprints-247082020-06-09T02:53:40Z http://eprints.um.edu.my/24708/ Growth hormone deficiency in adults Hew, Fen Lee Alford, Frank R Medicine Adults with Growth hormone (GH) deficiency is now being recognised to display many distinct clinical, metabolic and psychological abnormalities. It has been demonstrated that GI-I deficient (GHD) adults display features of multiple insulin resistant syndrome (MIRS) which predispose the GHD adults to increased cardiovascular morbidity and mortality. These features include central obesity, insulin resistance and glucose intolerance, hypertension, dyslipidaemia that includes a reduced level of high density lipoprotein cholesterol, an elevated triglyceride level and small low density lipoprotein cholesterol size. Furthermore, GHD adults are found to have a lower bone mass and a reduced sense of well-being. Replacement of GH in these GHD adults has brought about a major improvement in psychological well-being and central obesity. The improvement of some of the lipid abnormalities is however more modest. Insulin resistance, the corner stone of MIRS, is however not altered by GH replacement. Long term data is as yet unavailable to assess if GH replacement reduces cardiovascular mortality and morbidity in these subjects. Faculty of Medicine, University of Malaya 1999 Article PeerReviewed text en http://eprints.um.edu.my/24708/1/document%20%282%29.pdf Hew, Fen Lee and Alford, Frank (1999) Growth hormone deficiency in adults. Journal of the University of Malaya Medical Centre (JUMMEC), 4 (2). pp. 74-80. ISSN 1823-7339, https://jummec.um.edu.my/article/view/4438 |
| spellingShingle | R Medicine Hew, Fen Lee Alford, Frank Growth hormone deficiency in adults |
| title | Growth hormone deficiency in adults |
| title_full | Growth hormone deficiency in adults |
| title_fullStr | Growth hormone deficiency in adults |
| title_full_unstemmed | Growth hormone deficiency in adults |
| title_short | Growth hormone deficiency in adults |
| title_sort | growth hormone deficiency in adults |
| topic | R Medicine |
| url | http://eprints.um.edu.my/24708/1/document%20%282%29.pdf http://eprints.um.edu.my/24708/ https://jummec.um.edu.my/article/view/4438 |
| url_provider | http://eprints.um.edu.my/ |