Medical therapy for bleeding peptic ulcer
The majority of patients with upper gastrointestinal bleeding due to peptic ulcers stop bleeding spontaneously. The remainder of patients who have persistent or recurrent bleeding will require surgical or endoscopic intervention. Medical therapy provides an attractive alternative to these two treatm...
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Faculty of Medicine, University of Malaya
2000
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| Online Access: | http://eprints.um.edu.my/24521/ https://jummec.um.edu.my/article/view/4465 |
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| _version_ | 1831507866395082752 |
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| author | Ranjeev, P. Goh, Khean Lee |
| author_facet | Ranjeev, P. Goh, Khean Lee |
| author_sort | Ranjeev, P. |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | The majority of patients with upper gastrointestinal bleeding due to peptic ulcers stop bleeding spontaneously. The remainder of patients who have persistent or recurrent bleeding will require surgical or endoscopic intervention. Medical therapy provides an attractive alternative to these two treatment options. The advent of H2 antagonists in the mid 1970s revolutionized the treatment of peptic ulcer disease as it provided good ulcer healing with a treatment course of 6-8 weeks. A more potent acid suppressing class of drugs: the proton-pump inhibitors (PPl's) were introduced in the late 1980s and provided even better and faster ulcer healing. It was natural that the acid suppressing drugs were also used for the treatment of ulcer bleeding. Intravenous H2 antagonist and more recently intravenous PPI's have routinely been prescribed in many hospitals as soon as a bleeding patient is admitted. Critical evaluation of the literature shows, however, that H2 antagonists are no more effective than placebo in stopping ulcer bleeding. The PPI's, on the other hand, have been shown in several clinical studies to have a beneficial effect. The action of acid suppression in stopping ulcer bleeding is believed to be due to its effect in the stabilization of an ulcer clot by providing a high pH milieu and to commence the process of ulcer healing. |
| format | Article |
| id | my.um.eprints-24521 |
| institution | Universiti Malaya |
| publishDate | 2000 |
| publisher | Faculty of Medicine, University of Malaya |
| record_format | eprints |
| spelling | my.um.eprints-245212020-07-20T02:43:22Z http://eprints.um.edu.my/24521/ Medical therapy for bleeding peptic ulcer Ranjeev, P. Goh, Khean Lee R Medicine The majority of patients with upper gastrointestinal bleeding due to peptic ulcers stop bleeding spontaneously. The remainder of patients who have persistent or recurrent bleeding will require surgical or endoscopic intervention. Medical therapy provides an attractive alternative to these two treatment options. The advent of H2 antagonists in the mid 1970s revolutionized the treatment of peptic ulcer disease as it provided good ulcer healing with a treatment course of 6-8 weeks. A more potent acid suppressing class of drugs: the proton-pump inhibitors (PPl's) were introduced in the late 1980s and provided even better and faster ulcer healing. It was natural that the acid suppressing drugs were also used for the treatment of ulcer bleeding. Intravenous H2 antagonist and more recently intravenous PPI's have routinely been prescribed in many hospitals as soon as a bleeding patient is admitted. Critical evaluation of the literature shows, however, that H2 antagonists are no more effective than placebo in stopping ulcer bleeding. The PPI's, on the other hand, have been shown in several clinical studies to have a beneficial effect. The action of acid suppression in stopping ulcer bleeding is believed to be due to its effect in the stabilization of an ulcer clot by providing a high pH milieu and to commence the process of ulcer healing. Faculty of Medicine, University of Malaya 2000 Article PeerReviewed Ranjeev, P. and Goh, Khean Lee (2000) Medical therapy for bleeding peptic ulcer. Journal of the University of Malaya Medical Centre (JUMMEC), 5 (2). pp. 67-72. ISSN 1823-7339, https://jummec.um.edu.my/article/view/4465 |
| spellingShingle | R Medicine Ranjeev, P. Goh, Khean Lee Medical therapy for bleeding peptic ulcer |
| title | Medical therapy for bleeding peptic ulcer |
| title_full | Medical therapy for bleeding peptic ulcer |
| title_fullStr | Medical therapy for bleeding peptic ulcer |
| title_full_unstemmed | Medical therapy for bleeding peptic ulcer |
| title_short | Medical therapy for bleeding peptic ulcer |
| title_sort | medical therapy for bleeding peptic ulcer |
| topic | R Medicine |
| url | http://eprints.um.edu.my/24521/ https://jummec.um.edu.my/article/view/4465 |
| url_provider | http://eprints.um.edu.my/ |