Muscarinic receptor activity of some Malaysian plant species
Muscarinic receptor binding activity was tested on 224 plant extracts obtained from more than 50 plant families found in Malaysia. The plant extracts were evaluated by a 96-well microplate filtration–based radioligand competitive assay, centered on the ability of the plant extracts to competitive...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Taylor & Francis
2005
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/2451/1/Muscarinic_receptor_activity_of_some_Malaysian_plant_species.pdf http://eprints.um.edu.my/2451/ |
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| Summary: | Muscarinic receptor binding activity was tested on 224
plant extracts obtained from more than 50 plant families
found in Malaysia. The plant extracts were evaluated by
a 96-well microplate filtration–based radioligand competitive assay, centered on the ability of the plant extracts to competitively displace the radioligand, [3
H]N-methylscopolamine, from binding to the muscarinic membrane receptors. The screening assay was initially carried out at 50 mg=assay point, and those showing inhibition at and above 61% were retested at 10 mg=assay point. The extracts of Ficus septica Burm. f. (Moraceae) [65.85 � 3.75% inhibition; mean (n ¼ 3) � SD], Polyalthia microtus Miq. (Annonaceae) (32.63 � 1.38% inhibition), and
Popowia odoardoi Diels (Annonaceae) (35.79 � 7.11% inhibition) at 10 mg=assay point exhibited muscarinic properties, which are worthy of further investigation. |
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