Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta
Flavonoids are known to possess cardioprotective properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic flavonoid treatment on vascular endothelial functions in spontaneously hypertensive rats (SHR)....
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| Language: | en |
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Elsevier
2005
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| Online Access: | http://eprints.um.edu.my/2421/1/Chronic_Treatment_with_Flavonoids_Prevents.5.pdf http://eprints.um.edu.my/2421/ |
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| author | Ajay, M. Mustafa, Mohd Rais |
| author_facet | Ajay, M. Mustafa, Mohd Rais |
| author_sort | Ajay, M. |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Flavonoids are known to possess cardioprotective
properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic flavonoid treatment on vascular endothelial functions in spontaneously hypertensive rats (SHR). Starting from 6–7 weeks old, SHR were given flavonoids (baicalein, flavone, or quercetin) orally (10 mg/kg, once daily) to the SHRs for 4 weeks. Aortas from all the flavonoid-treated animals showed remarkably higher endothelium-dependent relaxations to acetylcholine, to a
similar extent as those pretreated with the angiotensin-converting enzyme inhibitor, captopril. However, in contrast to other experimental groups, flavone pretreatment also enhanced the endotheliumindependent relaxations to sodium nitroprusside. In addition, treatment with either flavone or quercetin induced a significant attenuation in systolic blood pressure of the hypertensive animals. The present
results suggest that chronic treatment with the flavonoids (baicalein, flavone, and quercetin) preserves vascular endothelial functions in hypertensive animals through several possible actions, including increasing endothelial nitric oxide production and bioavailability and reduction in blood pressure. |
| format | Article |
| id | my.um.eprints-2421 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2005 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | my.um.eprints-24212019-12-18T06:18:18Z http://eprints.um.edu.my/2421/ Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta Ajay, M. Mustafa, Mohd Rais RM Therapeutics. Pharmacology Flavonoids are known to possess cardioprotective properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic flavonoid treatment on vascular endothelial functions in spontaneously hypertensive rats (SHR). Starting from 6–7 weeks old, SHR were given flavonoids (baicalein, flavone, or quercetin) orally (10 mg/kg, once daily) to the SHRs for 4 weeks. Aortas from all the flavonoid-treated animals showed remarkably higher endothelium-dependent relaxations to acetylcholine, to a similar extent as those pretreated with the angiotensin-converting enzyme inhibitor, captopril. However, in contrast to other experimental groups, flavone pretreatment also enhanced the endotheliumindependent relaxations to sodium nitroprusside. In addition, treatment with either flavone or quercetin induced a significant attenuation in systolic blood pressure of the hypertensive animals. The present results suggest that chronic treatment with the flavonoids (baicalein, flavone, and quercetin) preserves vascular endothelial functions in hypertensive animals through several possible actions, including increasing endothelial nitric oxide production and bioavailability and reduction in blood pressure. Elsevier 2005-07 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2421/1/Chronic_Treatment_with_Flavonoids_Prevents.5.pdf Ajay, M. and Mustafa, Mohd Rais (2005) Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. Journal of Cardiovascular Pharmacology and Therapeutics, 46 (1). pp. 36-40. |
| spellingShingle | RM Therapeutics. Pharmacology Ajay, M. Mustafa, Mohd Rais Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title_full | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title_fullStr | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title_full_unstemmed | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title_short | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| title_sort | chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.um.edu.my/2421/1/Chronic_Treatment_with_Flavonoids_Prevents.5.pdf http://eprints.um.edu.my/2421/ |
| url_provider | http://eprints.um.edu.my/ |