Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells
Phyllanthus amarus which is locally known as Dukung Anak was one of the herb used in traditional medicine and research of P. amarus in Malaysia was not widely reported. This present research has isolated three chemical compounds and its anticancer effect of this species has been determined. Three li...
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2019
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| Online Access: | http://eprints.um.edu.my/23821/ https://doi.org/10.35940/ijrte.B1024.0782S719 |
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| author | Noor, Nur Affira Mohd Nafiah, Mohd Azlan Tuan Johari, Syed Ahmad Tajudin Hasnan, Muhammad Hafiz Husna Tan, Siow Ping Liew, Sook Yee Supratman, Unang |
| author_facet | Noor, Nur Affira Mohd Nafiah, Mohd Azlan Tuan Johari, Syed Ahmad Tajudin Hasnan, Muhammad Hafiz Husna Tan, Siow Ping Liew, Sook Yee Supratman, Unang |
| author_sort | Noor, Nur Affira Mohd |
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| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Phyllanthus amarus which is locally known as Dukung Anak was one of the herb used in traditional medicine and research of P. amarus in Malaysia was not widely reported. This present research has isolated three chemical compounds and its anticancer effect of this species has been determined. Three lignans namely hypophyllanthin was afforded from hexane crude while niranthin and lintetralin were afforded from ethanol crude. Anticancer test against HeLa cells and NIH/3T3 cells by MTT assays was tested for its anticancer effect. The result shows that hypophyllanthin was considered to possess an active anticancer effect on HeLa cells than NIH/3T3 cells compared to niranthin and lintetralin. © BEIESP. |
| format | Article |
| id | my.um.eprints-23821 |
| institution | Universiti Malaya |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | eprints |
| spelling | my.um.eprints-238212020-02-18T01:54:43Z http://eprints.um.edu.my/23821/ Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells Noor, Nur Affira Mohd Nafiah, Mohd Azlan Tuan Johari, Syed Ahmad Tajudin Hasnan, Muhammad Hafiz Husna Tan, Siow Ping Liew, Sook Yee Supratman, Unang Q Science (General) QD Chemistry Phyllanthus amarus which is locally known as Dukung Anak was one of the herb used in traditional medicine and research of P. amarus in Malaysia was not widely reported. This present research has isolated three chemical compounds and its anticancer effect of this species has been determined. Three lignans namely hypophyllanthin was afforded from hexane crude while niranthin and lintetralin were afforded from ethanol crude. Anticancer test against HeLa cells and NIH/3T3 cells by MTT assays was tested for its anticancer effect. The result shows that hypophyllanthin was considered to possess an active anticancer effect on HeLa cells than NIH/3T3 cells compared to niranthin and lintetralin. © BEIESP. MDPI 2019 Article PeerReviewed Noor, Nur Affira Mohd and Nafiah, Mohd Azlan and Tuan Johari, Syed Ahmad Tajudin and Hasnan, Muhammad Hafiz Husna and Tan, Siow Ping and Liew, Sook Yee and Supratman, Unang (2019) Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells. International Journal of Recent Technology and Engineering, 8 (2S7). pp. 106-110. ISSN 2277-3878, DOI https://doi.org/10.35940/ijrte.B1024.0782S719 <https://doi.org/10.35940/ijrte.B1024.0782S719>. https://doi.org/10.35940/ijrte.B1024.0782S719 doi:10.35940/ijrte.B1024.0782S719 |
| spellingShingle | Q Science (General) QD Chemistry Noor, Nur Affira Mohd Nafiah, Mohd Azlan Tuan Johari, Syed Ahmad Tajudin Hasnan, Muhammad Hafiz Husna Tan, Siow Ping Liew, Sook Yee Supratman, Unang Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title | Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title_full | Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title_fullStr | Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title_full_unstemmed | Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title_short | Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells And NIH/3T3 Cells |
| title_sort | anticancer effect of hypophyllanthin, niranthin and lintetralin from phyllanthus amarus on hela cells and nih/3t3 cells |
| topic | Q Science (General) QD Chemistry |
| url | http://eprints.um.edu.my/23821/ https://doi.org/10.35940/ijrte.B1024.0782S719 |
| url_provider | http://eprints.um.edu.my/ |