Dengue protease inhibition activity of selected malaysian medicinal herbs
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Malaysian Society of Parasitology and Tropical Medicine
2019
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/23552/ http://msptm.org/files/Vol36No2/357-366-Awang-K.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved. |
|---|