Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana
A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR an...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2019
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/23107/ https://doi.org/10.1021/acs.jnatprod.9b00712 |
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| Summary: | A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L, 7). Analysis of the spectroscopic data (NMR and MS) of these compounds led to the proposed structures of these alkaloids. The macroline-sarpagine alkaloids (1-6) showed in vitro growth inhibitory activity against a panel of human cancer cell lines, inclusive of KB, vincristine-resistant KB, PC-3, LNCaP, MCF7, MDA-MB-231, HT-29, HCT 116, and A549 cells (IC50 values: 0.02-9.0 μM). Copyright © 2019 American Chemical Society and American Society of Pharmacognosy. |
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