Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence?
Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsi...
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College of Pathologists, Academy of Medicine Malaysia
2018
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| author | Abdelrahim, Laila Mustafa Peh, Suat Cheng Kallarakkal, Thomas George |
| author_facet | Abdelrahim, Laila Mustafa Peh, Suat Cheng Kallarakkal, Thomas George |
| author_sort | Abdelrahim, Laila Mustafa |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the oral cavity and maxillofacial region using histological and immunophenotypical techniques and to determine its association with EBV infection. Materials and Methods: This was a descriptive cross-sectional study that included 14 cases of B-cell NHLs of the oral cavity and maxillofacial region. The haematopoietic and lymphoid tissue tumours classification of WHO was used to categorize the cases. In-situ hybridisation for EBV–encoded RNA was performed to confirm the EBV infection. Results: The average age of the patients included in the study was found to be 48.8 ± 23 years with a higher female to male ratio (1.3:1). Our study suggested that diffuse large B-cell lymphomas (DLBCLs) and Burkitt’s lymphomas (BLs) constitute the predominant subtypes of lymphomas affecting the oral cavity and maxillofacial regions. Conclusion: The findings from our study support the view that at least a relatively smaller proportion of B-cell NHLs that occur in the oral cavity and maxillofacial region do not have a pathogenic association with EBV. |
| format | Article |
| id | my.um.eprints-22749 |
| institution | Universiti Malaya |
| publishDate | 2018 |
| publisher | College of Pathologists, Academy of Medicine Malaysia |
| record_format | eprints |
| spelling | my.um.eprints-227492019-10-14T08:57:17Z http://eprints.um.edu.my/22749/ Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? Abdelrahim, Laila Mustafa Peh, Suat Cheng Kallarakkal, Thomas George RK Dentistry Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the oral cavity and maxillofacial region using histological and immunophenotypical techniques and to determine its association with EBV infection. Materials and Methods: This was a descriptive cross-sectional study that included 14 cases of B-cell NHLs of the oral cavity and maxillofacial region. The haematopoietic and lymphoid tissue tumours classification of WHO was used to categorize the cases. In-situ hybridisation for EBV–encoded RNA was performed to confirm the EBV infection. Results: The average age of the patients included in the study was found to be 48.8 ± 23 years with a higher female to male ratio (1.3:1). Our study suggested that diffuse large B-cell lymphomas (DLBCLs) and Burkitt’s lymphomas (BLs) constitute the predominant subtypes of lymphomas affecting the oral cavity and maxillofacial regions. Conclusion: The findings from our study support the view that at least a relatively smaller proportion of B-cell NHLs that occur in the oral cavity and maxillofacial region do not have a pathogenic association with EBV. College of Pathologists, Academy of Medicine Malaysia 2018 Article PeerReviewed Abdelrahim, Laila Mustafa and Peh, Suat Cheng and Kallarakkal, Thomas George (2018) Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? The Malaysian Journal of Pathology, 40 (1). pp. 49-56. ISSN 0126-8635, DOI PubMed ID: 29704384. http://www.mjpath.org.my/2018/v40n1/Epstein-Barr-virus-infection.pdf PubMed ID: 29704384 |
| spellingShingle | RK Dentistry Abdelrahim, Laila Mustafa Peh, Suat Cheng Kallarakkal, Thomas George Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title | Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title_full | Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title_fullStr | Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title_full_unstemmed | Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title_short | Epstein–barr virus infection in B-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: Is there any evidence? |
| title_sort | epstein–barr virus infection in b-cell non-hodgkin’s lymphomas of the oral and maxillofacial region: is there any evidence? |
| topic | RK Dentistry |
| url | http://eprints.um.edu.my/22749/ http://www.mjpath.org.my/2018/v40n1/Epstein-Barr-virus-infection.pdf |
| url_provider | http://eprints.um.edu.my/ |