Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell
Dengue virus (DENV) is maintained and circulated in both sylvatic/enzootic and endemic/human cycles and spill over infection of sylvatic DENV into human populations has been reported. Extensive deforestation and increase human activities in forest may increase the risk of human exposure to sylvatic...
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Malaysian Society of Parasitology and Tropical Medicine
2018
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| Online Access: | http://eprints.um.edu.my/22073/ http://msptm.org/files/Vol35No4/1154-1159-Chee-HY.pdf |
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| author | Fish-Low, Cheng Yee AbuBakar, Sazaly Othman, Fauziah Chee, Hui Yee |
| author_facet | Fish-Low, Cheng Yee AbuBakar, Sazaly Othman, Fauziah Chee, Hui Yee |
| author_sort | Fish-Low, Cheng Yee |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Dengue virus (DENV) is maintained and circulated in both sylvatic/enzootic and endemic/human cycles and spill over infection of sylvatic DENV into human populations has been reported. Extensive deforestation and increase human activities in forest may increase the risk of human exposure to sylvatic dengue infection and this may become a threat to human. Present study investigated the changes in cell morphology and viral morphogenesis upon infection with sylvatic and endemic ecotypes in human monocytic U-937 cells using transmission electron microscopy. Autophagy, a process that is either pro-viral or anti-viral, was observed in U-937 cells of both infections, however only the replication of endemic DENV was evidenced. An insight into the infection responses of sylvatic progenitors of DENV in susceptible host cells may provide better understanding on dengue emergence in human populations. |
| format | Article |
| id | my.um.eprints-22073 |
| institution | Universiti Malaya |
| publishDate | 2018 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| record_format | eprints |
| spelling | my.um.eprints-220732019-08-26T06:31:37Z http://eprints.um.edu.my/22073/ Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell Fish-Low, Cheng Yee AbuBakar, Sazaly Othman, Fauziah Chee, Hui Yee R Medicine Dengue virus (DENV) is maintained and circulated in both sylvatic/enzootic and endemic/human cycles and spill over infection of sylvatic DENV into human populations has been reported. Extensive deforestation and increase human activities in forest may increase the risk of human exposure to sylvatic dengue infection and this may become a threat to human. Present study investigated the changes in cell morphology and viral morphogenesis upon infection with sylvatic and endemic ecotypes in human monocytic U-937 cells using transmission electron microscopy. Autophagy, a process that is either pro-viral or anti-viral, was observed in U-937 cells of both infections, however only the replication of endemic DENV was evidenced. An insight into the infection responses of sylvatic progenitors of DENV in susceptible host cells may provide better understanding on dengue emergence in human populations. Malaysian Society of Parasitology and Tropical Medicine 2018 Article PeerReviewed Fish-Low, Cheng Yee and AbuBakar, Sazaly and Othman, Fauziah and Chee, Hui Yee (2018) Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell. Tropical Biomedicine, 35 (4). pp. 1154-1159. ISSN 0127-5720, http://msptm.org/files/Vol35No4/1154-1159-Chee-HY.pdf |
| spellingShingle | R Medicine Fish-Low, Cheng Yee AbuBakar, Sazaly Othman, Fauziah Chee, Hui Yee Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title | Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title_full | Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title_fullStr | Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title_full_unstemmed | Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title_short | Ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic U-937 cell |
| title_sort | ultrastructural changes of cell morphology and viral morphogenesis of two ecotypes of dengue virus infection in human monocytic u-937 cell |
| topic | R Medicine |
| url | http://eprints.um.edu.my/22073/ http://msptm.org/files/Vol35No4/1154-1159-Chee-HY.pdf |
| url_provider | http://eprints.um.edu.my/ |