Thraatchathi chooranam, protects cardiomyocytes against oxidative stress
Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 mg/ml) of...
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Frontiers in Bioscience
2018
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| Online Access: | http://eprints.um.edu.my/22049/ https://www.bioscience.org/2018/v10e/af/831/list.htm |
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| author | Ganapathy, Ramakrishnan Mani, Sugumar Raghavendran, Hanumanth Rao Balaji Kamarul, Tunku Ray, Bipul Bhat, Abid Chidambaram, Saravana Babu |
| author_facet | Ganapathy, Ramakrishnan Mani, Sugumar Raghavendran, Hanumanth Rao Balaji Kamarul, Tunku Ray, Bipul Bhat, Abid Chidambaram, Saravana Babu |
| author_sort | Ganapathy, Ramakrishnan |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 mg/ml) of TC. Pretreatment of cells with TC upregulated antiapoptotic Bcl2, and anti-oxidants TRX1 and TRXR and downregulated Bax and HIF-α and inflammatory genes iNOS and TNF-α. Together, these findings show that TC has both anti-oxidant and anti-apoptotic properties. Further studies may be considered to identify the bioactive principle(s) and precise mechanisms of action of TC. |
| format | Article |
| id | my.um.eprints-22049 |
| institution | Universiti Malaya |
| publishDate | 2018 |
| publisher | Frontiers in Bioscience |
| record_format | eprints |
| spelling | my.um.eprints-220492019-08-26T02:11:34Z http://eprints.um.edu.my/22049/ Thraatchathi chooranam, protects cardiomyocytes against oxidative stress Ganapathy, Ramakrishnan Mani, Sugumar Raghavendran, Hanumanth Rao Balaji Kamarul, Tunku Ray, Bipul Bhat, Abid Chidambaram, Saravana Babu R Medicine Thraatchathi Chooranam (TC), is a polyphenol-rich Indian traditional medicine. Present study was undertaken to investigate the effects of TC against H2O2 induced oxidative stress and apoptotic damage in H9C2 cardiomyocytes. Cell viability assay indicated relative safety (IC50= 488.10±12.04 mg/ml) of TC. Pretreatment of cells with TC upregulated antiapoptotic Bcl2, and anti-oxidants TRX1 and TRXR and downregulated Bax and HIF-α and inflammatory genes iNOS and TNF-α. Together, these findings show that TC has both anti-oxidant and anti-apoptotic properties. Further studies may be considered to identify the bioactive principle(s) and precise mechanisms of action of TC. Frontiers in Bioscience 2018 Article PeerReviewed Ganapathy, Ramakrishnan and Mani, Sugumar and Raghavendran, Hanumanth Rao Balaji and Kamarul, Tunku and Ray, Bipul and Bhat, Abid and Chidambaram, Saravana Babu (2018) Thraatchathi chooranam, protects cardiomyocytes against oxidative stress. Frontiers in Bioscience, Elite, 10 (3). pp. 437-448. ISSN 1945-0494, https://www.bioscience.org/2018/v10e/af/831/list.htm |
| spellingShingle | R Medicine Ganapathy, Ramakrishnan Mani, Sugumar Raghavendran, Hanumanth Rao Balaji Kamarul, Tunku Ray, Bipul Bhat, Abid Chidambaram, Saravana Babu Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title | Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title_full | Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title_fullStr | Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title_full_unstemmed | Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title_short | Thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| title_sort | thraatchathi chooranam, protects cardiomyocytes against oxidative stress |
| topic | R Medicine |
| url | http://eprints.um.edu.my/22049/ https://www.bioscience.org/2018/v10e/af/831/list.htm |
| url_provider | http://eprints.um.edu.my/ |