Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists

In this study, the (S)-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were prepared via a synthetic route involving catalytic asymmetric hydrogenation and both stereoisomers were evaluated in vitro for functional activity at human 5-HT2 and adrenergic α1 receptor subtypes using a...

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Main Authors:	Heng, Hui Li, Chee, Chin Fei, Chin, Sek Peng, Ouyang, Yifan, Wang, Hao, Buckle, Michael James Christopher, Herr, Deron R., Paterson, Ian Charles, Doughty, Stephen W., Abd Rahman, Noorsaadah, Chung, Lip Yong
Format:	Article
Published:	Royal Society of Chemistry 2018
Subjects:	Q Science (General) QD Chemistry R Medicine
Online Access:	http://eprints.um.edu.my/21903/ https://doi.org/10.1039/c7md00629b
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