Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene-Derived Cyclohexenyl Chalcones

Based on a bioinspired asymmetric Diels–Alder cycloaddition using a chiral Evans oxazolidinone, the first total synthesis of both enantiomers of two myrcene-derived cyclohexenyl chalcones, fislatifolione and fislatifolic acid, has been carried out. This strategy was also applied to the total synthes...

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Main Authors:	Tiamas, Shelly Gapil, Audet, Florian, Samra, Alma Abou, Bignon, Jérome, Litaudon, Marc, Fourneau, Christophe, Ariffin, Azhar, Awang, Khalijah, Desrat, Sandy, Roussi, Fanny
Format:	Article
Published:	Wiley 2018
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://eprints.um.edu.my/20469/ https://doi.org/10.1002/ejoc.201800262
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