Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals
Purpose: This study compared pain sensitivity among opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive subjects. Methods: The three hundred participants comprised 152 opioid naive subjects and 148 opioid dependent patients. Opioid naive subjects had not taken any opioi...
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Canadian Society for Pharmaceutical Sciences
2016
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| Online Access: | http://eprints.um.edu.my/18721/ http://dx.doi.org/10.18433/J3NS49 |
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| author | Zahari, Z. Lee, C.S. Ibrahim, M.A. Musa, N. Mohd Yasin, M.A. Lee, Y.Y. Tan, S.C. Mohamad, N. Ismail, R. |
| author_facet | Zahari, Z. Lee, C.S. Ibrahim, M.A. Musa, N. Mohd Yasin, M.A. Lee, Y.Y. Tan, S.C. Mohamad, N. Ismail, R. |
| author_sort | Zahari, Z. |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | Purpose: This study compared pain sensitivity among opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive subjects. Methods: The three hundred participants comprised 152 opioid naive subjects and 148 opioid dependent patients. Opioid naive subjects had not taken any opioids including morphine and methadone to their best knowledge and were presumed so after two consecutive negative urine screenings for drugs. All opioid dependent patients were stabilized in treatment, defined as having been enrolled in the program for more than one month with no change of methadone dosage over the past one month. Excluded from the study were individuals with chronic or ongoing acute pain and individuals with a history of analgesics ingestion within 3 d before the cold pressor test (CPT). Pain tolerance to CPT was evaluated at 0 h, and at 2, 4, 8, 12, and 24 h post-methadone dose. Results: Patients exhibited a significantly shorter mean pain tolerance time of 34.17 s (95% CI 24.86, 43.49) versus 61.36 (52.23, 70.48) [p < 0.001] compared with opioid naive subjects. Time-dependent mean pain tolerance was also significantly different when naive subjects were compared to patients (p = 0.016). Conclusions: This study revealed hyperalgesia amongst patients on MMT, as manifested by their quicker hand withdrawal. The complaints of pain in this population should not be underestimated and the pain should be evaluated seriously and managed aggressively. |
| format | Article |
| id | my.um.eprints-18721 |
| institution | Universiti Malaya |
| publishDate | 2016 |
| publisher | Canadian Society for Pharmaceutical Sciences |
| record_format | eprints |
| spelling | my.um.eprints-187212018-05-18T01:16:34Z http://eprints.um.edu.my/18721/ Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals Zahari, Z. Lee, C.S. Ibrahim, M.A. Musa, N. Mohd Yasin, M.A. Lee, Y.Y. Tan, S.C. Mohamad, N. Ismail, R. R Medicine Purpose: This study compared pain sensitivity among opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive subjects. Methods: The three hundred participants comprised 152 opioid naive subjects and 148 opioid dependent patients. Opioid naive subjects had not taken any opioids including morphine and methadone to their best knowledge and were presumed so after two consecutive negative urine screenings for drugs. All opioid dependent patients were stabilized in treatment, defined as having been enrolled in the program for more than one month with no change of methadone dosage over the past one month. Excluded from the study were individuals with chronic or ongoing acute pain and individuals with a history of analgesics ingestion within 3 d before the cold pressor test (CPT). Pain tolerance to CPT was evaluated at 0 h, and at 2, 4, 8, 12, and 24 h post-methadone dose. Results: Patients exhibited a significantly shorter mean pain tolerance time of 34.17 s (95% CI 24.86, 43.49) versus 61.36 (52.23, 70.48) [p < 0.001] compared with opioid naive subjects. Time-dependent mean pain tolerance was also significantly different when naive subjects were compared to patients (p = 0.016). Conclusions: This study revealed hyperalgesia amongst patients on MMT, as manifested by their quicker hand withdrawal. The complaints of pain in this population should not be underestimated and the pain should be evaluated seriously and managed aggressively. Canadian Society for Pharmaceutical Sciences 2016 Article PeerReviewed Zahari, Z. and Lee, C.S. and Ibrahim, M.A. and Musa, N. and Mohd Yasin, M.A. and Lee, Y.Y. and Tan, S.C. and Mohamad, N. and Ismail, R. (2016) Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals. Journal of Pharmacy and Pharmaceutical Sciences, 19 (1). pp. 127-136. ISSN 1482-1826, DOI PubMed ID: 27096697. http://dx.doi.org/10.18433/J3NS49 PubMed ID: 27096697 |
| spellingShingle | R Medicine Zahari, Z. Lee, C.S. Ibrahim, M.A. Musa, N. Mohd Yasin, M.A. Lee, Y.Y. Tan, S.C. Mohamad, N. Ismail, R. Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title | Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title_full | Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title_fullStr | Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title_full_unstemmed | Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title_short | Comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (MMT) and opioid naive individuals |
| title_sort | comparison of pain tolerance between opioid dependent patients on methadone maintenance therapy (mmt) and opioid naive individuals |
| topic | R Medicine |
| url | http://eprints.um.edu.my/18721/ http://dx.doi.org/10.18433/J3NS49 |
| url_provider | http://eprints.um.edu.my/ |