Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic Acid by Rhizopus arrhizus

In our search for inhibitors of the antiapoptotic protein Bcl-xL, investigation of Xylopia caudata afforded a new diterpenoid, ent-trachyloban-4 beta-ol (2), and five known ent-trachylobane or ent-atisane compounds. Only ent-trachyloban-18-oic acid (1) exhibited weak binding activity to Bcl-xL. Thes...

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Bibliographic Details

Main Authors:	Leverrier, A., Martin, Marie-Therese, Servy, C., Ouazzani, J., Retailleau, P., Awang, Khalijah, Mukhtar, M.R., Gueritte, F., Litaudon, M.
Format:	Article
Published:	American Chemical Society 2010
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/13387/
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