Interplay of transcription factors in T-cell differentiation and function: the role of Runx
Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes’ entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Blackwell Publishing
2011
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/13025/ http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2010.03381.x/abstract http://dx.doi.org/10.1111/j.1365-2567.2010.03381.x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes’ entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interplay with these master regulators in various aspects of T cells’ immunity. In this review article, we first explain roles of Th-Pok and Runx3 in differentiation of CD4 versus CD8 single positive cells, and later focus on cross-regulation of Th-Pok and Runx3 and their relationship with other factors such as TCR strength. Next, we provide evidences for the direct interplay of Runx1/3 with T-bet and GATA3 during Th1 versus Th2 commitment to activate or silence transcription of signature cytokine genes, IFNγ and IL4. Lastly, we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells’ suppressive activity. This review highlights an essential importance of Runx molecules in controlling various T cell subsets’ differentiation and functions through molecular interplay with the master transcription factors in terms of protein-protein interaction as well as regulation of gene expression. |
|---|