2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans
Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript...
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| Main Authors: | , , , , , |
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| Format: | Article |
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John Wiley & Sons
2009
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/13022/ http://onlinelibrary.wiley.com/doi/10.1002/jobm.200900035/abstract;jsessionid=FF932426565968444C3570783479C42F.f04t04 http://dx.doi.org/10.1002/jobm.200900035 |
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| Summary: | Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade. |
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