Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters
The aim of the present study was to evaluate the association between the paraoxonase 1 (PON1) L55M and Q192R polymorphisms and breast cancer risk as well as clinico-pathological characteristics of the patients. Genotyping of these polymorphisms was performed using polymerase chain reaction-restricti...
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2010
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| author | Naidu, R. Har, Y.C. Taib, N.A.M. |
| author_facet | Naidu, R. Har, Y.C. Taib, N.A.M. |
| author_sort | Naidu, R. |
| building | UM Library |
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| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | The aim of the present study was to evaluate the association between the paraoxonase 1 (PON1) L55M and Q192R polymorphisms and breast cancer risk as well as clinico-pathological characteristics of the patients. Genotyping of these polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population. Peripheral blood samples were collected from 387 breast cancer patients and 252 normal and healthy women who had no history of any malignancy. The genotype (P=0.023) and allele (P=0.008) frequencies of L55M polymorphism were significantly different between the breast cancer cases and normal individuals. However, the distribution of genotype (P=0.333) and allele (P= 0.163) frequencies of Q192R polymorphism showed lack of statistical significance. Women who were MM homozygotes (OR=2.229; 95% CI, 1.219-4.075) and carriers of M allele genotype (OR=1.429; 95% CI, 1.035-1.974) or M allele (OR=1.397; 95% CI, 1.093-1.785) were associated with increased risk of breast cancer. However, women who were heterozygous (OR=0.793; 95% CI, 0.567-1.110) or homozygous (OR=0.746; 95% CI, 0.407-1.370) for R allele or carriers of R allele (OR=0.838; 95%, 0.654-1.074) were not associated with breast cancer risk. The M allele genotype was significantly associated with estrogen receptor negativity (P=0.046) and nodal involvement (P=0.004) but R allele genotype was not associated with any of the clinico-pathological characteristics. In conclusion, our findings suggest that the polymorphic variant of L55M polymorphism could be a useful genetic marker for tumor prognosis and to identify women who might be at greater risk of developing breast cancer in a hospital-based Malaysian population. |
| format | Article |
| id | my.um.eprints-11921 |
| institution | Universiti Malaya |
| publishDate | 2010 |
| publisher | Springer |
| record_format | eprints |
| spelling | my.um.eprints-119212015-01-13T06:49:50Z http://eprints.um.edu.my/11921/ Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters Naidu, R. Har, Y.C. Taib, N.A.M. R Medicine The aim of the present study was to evaluate the association between the paraoxonase 1 (PON1) L55M and Q192R polymorphisms and breast cancer risk as well as clinico-pathological characteristics of the patients. Genotyping of these polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population. Peripheral blood samples were collected from 387 breast cancer patients and 252 normal and healthy women who had no history of any malignancy. The genotype (P=0.023) and allele (P=0.008) frequencies of L55M polymorphism were significantly different between the breast cancer cases and normal individuals. However, the distribution of genotype (P=0.333) and allele (P= 0.163) frequencies of Q192R polymorphism showed lack of statistical significance. Women who were MM homozygotes (OR=2.229; 95% CI, 1.219-4.075) and carriers of M allele genotype (OR=1.429; 95% CI, 1.035-1.974) or M allele (OR=1.397; 95% CI, 1.093-1.785) were associated with increased risk of breast cancer. However, women who were heterozygous (OR=0.793; 95% CI, 0.567-1.110) or homozygous (OR=0.746; 95% CI, 0.407-1.370) for R allele or carriers of R allele (OR=0.838; 95%, 0.654-1.074) were not associated with breast cancer risk. The M allele genotype was significantly associated with estrogen receptor negativity (P=0.046) and nodal involvement (P=0.004) but R allele genotype was not associated with any of the clinico-pathological characteristics. In conclusion, our findings suggest that the polymorphic variant of L55M polymorphism could be a useful genetic marker for tumor prognosis and to identify women who might be at greater risk of developing breast cancer in a hospital-based Malaysian population. Springer 2010 Article PeerReviewed Naidu, R. and Har, Y.C. and Taib, N.A.M. (2010) Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters. Pathology & Oncology Research , 16 (4). pp. 533-540. |
| spellingShingle | R Medicine Naidu, R. Har, Y.C. Taib, N.A.M. Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title | Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title_full | Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title_fullStr | Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title_full_unstemmed | Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title_short | Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters |
| title_sort | genetic polymorphisms of paraoxonase 1 (pon1) gene: association between l55m or q192r with breast cancer risk and clinico-pathological parameters |
| topic | R Medicine |
| url | http://eprints.um.edu.my/11921/ |
| url_provider | http://eprints.um.edu.my/ |