MicroRNA pathways: An emerging role in identification of therapeutic strategies
For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory ne...
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| Format: | Article |
| Language: | en |
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2014
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| Online Access: | http://eprints.um.edu.my/11366/1/MicroRNA_pathways_an_emerging_role_in_identification_of_therapeutic_strategies.pdf http://eprints.um.edu.my/11366/ |
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| author | Vijayarathna, S. Oon, C.E. Jothy, S.L. Chen, Y. Kanwar, J.R. Sasidharan, S. |
| author_facet | Vijayarathna, S. Oon, C.E. Jothy, S.L. Chen, Y. Kanwar, J.R. Sasidharan, S. |
| author_sort | Vijayarathna, S. |
| building | UM Library |
| collection | Institutional Repository |
| content_provider | Universiti Malaya |
| content_source | UM Research Repository |
| continent | Asia |
| country | Malaysia |
| description | For years researchers have exerted every effort to improve the influential roles of microRNA
(miRNA) in regulating genes that direct mammalian cell development and function. In spite of
numerous advancements, many facets of miRNA generation remain unresolved due to the
perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no
universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in
biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual
miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are
generated and function will help with diagnostic tools and therapeutic strategies. This review
encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while
elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs. |
| format | Article |
| id | my.um.eprints-11366 |
| institution | Universiti Malaya |
| language | en |
| publishDate | 2014 |
| record_format | eprints |
| spelling | my.um.eprints-113662014-11-20T02:06:34Z http://eprints.um.edu.my/11366/ MicroRNA pathways: An emerging role in identification of therapeutic strategies Vijayarathna, S. Oon, C.E. Jothy, S.L. Chen, Y. Kanwar, J.R. Sasidharan, S. RK Dentistry For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs. 2014 Article PeerReviewed application/pdf en http://eprints.um.edu.my/11366/1/MicroRNA_pathways_an_emerging_role_in_identification_of_therapeutic_strategies.pdf Vijayarathna, S. and Oon, C.E. and Jothy, S.L. and Chen, Y. and Kanwar, J.R. and Sasidharan, S. (2014) MicroRNA pathways: An emerging role in identification of therapeutic strategies. Current Gene Therapy, 14 (2). pp. 112-120. ISSN 1566-5232, |
| spellingShingle | RK Dentistry Vijayarathna, S. Oon, C.E. Jothy, S.L. Chen, Y. Kanwar, J.R. Sasidharan, S. MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title | MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title_full | MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title_fullStr | MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title_full_unstemmed | MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title_short | MicroRNA pathways: An emerging role in identification of therapeutic strategies |
| title_sort | microrna pathways: an emerging role in identification of therapeutic strategies |
| topic | RK Dentistry |
| url | http://eprints.um.edu.my/11366/1/MicroRNA_pathways_an_emerging_role_in_identification_of_therapeutic_strategies.pdf http://eprints.um.edu.my/11366/ |
| url_provider | http://eprints.um.edu.my/ |