Rotavirus genotypes in Malaysia and universal rotavirus vaccination
Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the eff ectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Taylor & Francis
2012
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10604/1/Rotavirus_genotypes_in_Malaysia_and_Universal.pdf http://eprints.um.edu.my/10604/ |
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| Summary: | Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the eff ectiveness of a universal RV-A
vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective
study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and
genotypes, mortality on childhood GE, and published genotype-specifi c effi cacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected eff ectiveness was 75.7% to 88.1% for Rotateq® and 78.7% to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq® and 28 to 32 deaths annually forRotarix®. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia. |
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