The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia
Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en |
| Published: |
BioMed Central
2012
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10546/1/Detection_of_pfcrt_and_pfmdr1_point_mutations_as_molecular_markers_of_chloroquine_drug_resistance%2C_Pahang%2C_Malaysia.pdf http://eprints.um.edu.my/10546/ |
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| Summary: | Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance |
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