Rhazinilam−leuconolam−leuconoxine alkaloids from leuconotis griffithii
Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
American Chemical Society
2013
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/10373/1/Rhazinilam%E2%88%92Leuconolam%E2%88%92Leuconoxine_Alkaloids_from_Leuconotis.pdf http://eprints.um.edu.my/10373/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines A–E (4–8). The structures of these alkaloids were determined using NMR and MS analyses and in some instances confirmed by X-ray diffraction analyses. Alkaloids 1, 5, and 7 showed only moderate to weak cytotoxicity toward KB cells (IC50 12–18 μg/mL), while 8 showed moderate activity in reversing MDR in vincristine-resistant KB cells. |
|---|