Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed amon...
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| Format: | Thesis |
| Language: | en |
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2006
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| Online Access: | https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF https://ir.uitm.edu.my/id/eprint/99042/ |
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| _version_ | 1833321416292827136 |
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| author | Maasah, Ros Azima |
| author_facet | Maasah, Ros Azima |
| author_sort | Maasah, Ros Azima |
| building | Tun Abdul Razak Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Mara |
| content_source | UiTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed among the prominent approaches to synthesise stilbene. However, isomers are reported to form. Thus, regioselectivity become the concern of most studies. With appropriate reaction condition, regioselectivity is claimed achievable. Preformed active species of Pd is claimed preferable rather than attempting to generate active species in situ. This study is carried out to synthesise a stilbene analogue, trans-3,4-dimethoxy-11-benzyloxystilbene ! using Heck reaction with several reaction conditions and to observe effect of using preformed Pd(O) and in situ Pd(II) on yield of ]. ! was characterised using spectroscopy method (IR and NMR). Melting point of! was also determined. All reaction conditions chosen were appropriate to synthesise !. However, valid comparison between the yield of generated active species in situ and preformed active species from a Pd(O) or Pd(II) source cannot be compared. This is because the quantification method chosen are inappropriate. Thus, it is concluded that not only appropriate reaction condition is needed for regioselectivity, but appropriate quantification method also needs to be considered. |
| format | Thesis |
| id | my.uitm.ir-99042 |
| institution | Universiti Teknologi Mara |
| language | en |
| publishDate | 2006 |
| record_format | eprints |
| spelling | my.uitm.ir-990422024-07-24T03:07:46Z https://ir.uitm.edu.my/id/eprint/99042/ Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah Maasah, Ros Azima RM Therapeutics. Pharmacology RS Pharmacy and materia medica Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed among the prominent approaches to synthesise stilbene. However, isomers are reported to form. Thus, regioselectivity become the concern of most studies. With appropriate reaction condition, regioselectivity is claimed achievable. Preformed active species of Pd is claimed preferable rather than attempting to generate active species in situ. This study is carried out to synthesise a stilbene analogue, trans-3,4-dimethoxy-11-benzyloxystilbene ! using Heck reaction with several reaction conditions and to observe effect of using preformed Pd(O) and in situ Pd(II) on yield of ]. ! was characterised using spectroscopy method (IR and NMR). Melting point of! was also determined. All reaction conditions chosen were appropriate to synthesise !. However, valid comparison between the yield of generated active species in situ and preformed active species from a Pd(O) or Pd(II) source cannot be compared. This is because the quantification method chosen are inappropriate. Thus, it is concluded that not only appropriate reaction condition is needed for regioselectivity, but appropriate quantification method also needs to be considered. 2006 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah. (2006) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam). |
| spellingShingle | RM Therapeutics. Pharmacology RS Pharmacy and materia medica Maasah, Ros Azima Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title | Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title_full | Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title_fullStr | Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title_full_unstemmed | Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title_short | Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah |
| title_sort | synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / ros azima maasah |
| topic | RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF https://ir.uitm.edu.my/id/eprint/99042/ |
| url_provider | http://ir.uitm.edu.my/ |