Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.]
Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance o...
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| Language: | en |
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Universiti Teknologi MARA Cawangan Selangor
2021
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| Online Access: | https://ir.uitm.edu.my/id/eprint/44352/1/44352.pdf https://ir.uitm.edu.my/id/eprint/44352/ https://jchs-medicine.uitm.edu.my/index.php |
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| author | Barkatullah, Islam Ahmad, Syed Shamshad Akhtar, Kafil Mansoor, Tariq |
| author_facet | Barkatullah, Islam Ahmad, Syed Shamshad Akhtar, Kafil Mansoor, Tariq |
| author_sort | Barkatullah, Islam |
| building | Tun Abdul Razak Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Mara |
| content_source | UiTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance of serum HER-2/neu concentration with tissue HER-2/neu immunohistochemistry and determine its relationship with various prognostic indicators like age, size of tumour, lymph node status, grade, and stage of tumour. Methods: The preoperative serum samples of 56 clinically and cytologically diagnosed cases of breast carcinoma were taken and postoperative mastectomy specimens were examined for the histologic type, lympho-vascular invasion, stage, and grade of the tumour. Immunohistochemical study of HER-2/neu expression and HER-2/neu serum biochemistry was studied. Results: Age of the patients ranged from 25-75 years. Twenty-three cases (41.1%) were premenopausal while 33 cases (58.9%) postmenopausal. Forty-seven cases (83.9%) were of the infiltrating ductal carcinoma (NOS) type. Serum positivity for HER-2/neu was noted in 29 (51.8%) cases. Serum HER-2/neu levels showed a positive correlation with increase in tumour size, grade, stage of tumour and lymph node involvement. Serum HER- 2/neu positivity was seen in 20 (68.9%) IHC positive patients and 9 (33.3%) IHC negative patients, with a statistically significant correlation (p=0.005). Conclusion: Serum HER-2/neu levels directly correlate with prognostic factors like tumour size, grade, stage of the tumour and lymph node metastasis and can be used as a complimentary tool to tissue HER-2/neu immunohistochemistry. |
| format | Article |
| id | my.uitm.ir-44352 |
| institution | Universiti Teknologi Mara |
| language | en |
| publishDate | 2021 |
| publisher | Universiti Teknologi MARA Cawangan Selangor |
| record_format | eprints |
| spelling | my.uitm.ir-443522021-03-29T05:06:28Z https://ir.uitm.edu.my/id/eprint/44352/ Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] jchs Barkatullah, Islam Ahmad, Syed Shamshad Akhtar, Kafil Mansoor, Tariq Diseases of the breast Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance of serum HER-2/neu concentration with tissue HER-2/neu immunohistochemistry and determine its relationship with various prognostic indicators like age, size of tumour, lymph node status, grade, and stage of tumour. Methods: The preoperative serum samples of 56 clinically and cytologically diagnosed cases of breast carcinoma were taken and postoperative mastectomy specimens were examined for the histologic type, lympho-vascular invasion, stage, and grade of the tumour. Immunohistochemical study of HER-2/neu expression and HER-2/neu serum biochemistry was studied. Results: Age of the patients ranged from 25-75 years. Twenty-three cases (41.1%) were premenopausal while 33 cases (58.9%) postmenopausal. Forty-seven cases (83.9%) were of the infiltrating ductal carcinoma (NOS) type. Serum positivity for HER-2/neu was noted in 29 (51.8%) cases. Serum HER-2/neu levels showed a positive correlation with increase in tumour size, grade, stage of tumour and lymph node involvement. Serum HER- 2/neu positivity was seen in 20 (68.9%) IHC positive patients and 9 (33.3%) IHC negative patients, with a statistically significant correlation (p=0.005). Conclusion: Serum HER-2/neu levels directly correlate with prognostic factors like tumour size, grade, stage of the tumour and lymph node metastasis and can be used as a complimentary tool to tissue HER-2/neu immunohistochemistry. Universiti Teknologi MARA Cawangan Selangor 2021-03-01 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/44352/1/44352.pdf Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.]. (2021) Journal of Clinical and Health Sciences <https://ir.uitm.edu.my/view/publication/Journal_of_Clinical_and_Health_Sciences/>, 6 (1). pp. 18-24. ISSN 0127-984X https://jchs-medicine.uitm.edu.my/index.php |
| spellingShingle | Diseases of the breast Barkatullah, Islam Ahmad, Syed Shamshad Akhtar, Kafil Mansoor, Tariq Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title_full | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title_fullStr | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title_full_unstemmed | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title_short | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma / Islam Barkatullah ... [et al.] |
| title_sort | correlation of serum her-2/neu levels with clinico-pathological variables and tissue immunohistochemistry in breast carcinoma / islam barkatullah ... [et al.] |
| topic | Diseases of the breast |
| url | https://ir.uitm.edu.my/id/eprint/44352/1/44352.pdf https://ir.uitm.edu.my/id/eprint/44352/ https://jchs-medicine.uitm.edu.my/index.php |
| url_provider | http://ir.uitm.edu.my/ |