Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani
Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via poly...
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Universiti Teknologi MARA Cawangan Pulau Pinang
2017
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| Online Access: | https://ir.uitm.edu.my/id/eprint/28775/1/AJ_ADZLY%20H.%20SAHABUDIN%20EAJ%2017.pdf https://ir.uitm.edu.my/id/eprint/28775/ https://uppp.uitm.edu.my |
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| author | H. Sahabudin, Adzly Foong, Fiona How Ni Abdul Ghani, Radiah |
| author_facet | H. Sahabudin, Adzly Foong, Fiona How Ni Abdul Ghani, Radiah |
| author_sort | H. Sahabudin, Adzly |
| building | Tun Abdul Razak Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Mara |
| content_source | UiTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogues was succesfully synthesis with the expected structures |
| format | Article |
| id | my.uitm.ir-28775 |
| institution | Universiti Teknologi Mara |
| language | en |
| publishDate | 2017 |
| publisher | Universiti Teknologi MARA Cawangan Pulau Pinang |
| record_format | eprints |
| spelling | my.uitm.ir-287752025-07-02T06:29:11Z https://ir.uitm.edu.my/id/eprint/28775/ Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani esteem H. Sahabudin, Adzly Foong, Fiona How Ni Abdul Ghani, Radiah Cancer Research. Experimentation Biotechnology Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogues was succesfully synthesis with the expected structures Universiti Teknologi MARA Cawangan Pulau Pinang 2017-08 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/28775/1/AJ_ADZLY%20H.%20SAHABUDIN%20EAJ%2017.pdf Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani. (2017) ESTEEM Academic Journal <https://ir.uitm.edu.my/view/publication/ESTEEM_Academic_Journal.html>, 13 (SI). pp. 91-97. ISSN 2289-4934 https://uppp.uitm.edu.my |
| spellingShingle | Cancer Research. Experimentation Biotechnology H. Sahabudin, Adzly Foong, Fiona How Ni Abdul Ghani, Radiah Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title | Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title_full | Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title_fullStr | Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title_full_unstemmed | Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title_short | Synthesis and characterization of putrescine-sulfur analogue/ Adzly H. Sahabudin, Fiona How Ni Foong and Radiah Abdul Ghani |
| title_sort | synthesis and characterization of putrescine-sulfur analogue/ adzly h. sahabudin, fiona how ni foong and radiah abdul ghani |
| topic | Cancer Research. Experimentation Biotechnology |
| url | https://ir.uitm.edu.my/id/eprint/28775/1/AJ_ADZLY%20H.%20SAHABUDIN%20EAJ%2017.pdf https://ir.uitm.edu.my/id/eprint/28775/ https://uppp.uitm.edu.my |
| url_provider | http://ir.uitm.edu.my/ |