Cytotoxic evaluation of 6-metoxy tetrahydro-β-carboline derivatives (6mthβc) in human neuroblastoma (sk-n-sh) cells
Tetrahydro-β-carboline (THβC) alkaloids, a varied group of indole-derived chemicals, demonstrate pharmacological actions including anticancer, antibacterial, antioxidant, and neuroactive effects in nature. In this study, 6-methoxy-tetrahydro-β-carboline (6MTHβC) has been synthesized and evaluated fo...
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| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | en |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/131411/1/131411.pdf https://ir.uitm.edu.my/id/eprint/131411/ |
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| Summary: | Tetrahydro-β-carboline (THβC) alkaloids, a varied group of indole-derived chemicals, demonstrate pharmacological actions including anticancer, antibacterial, antioxidant, and neuroactive effects in nature. In this study, 6-methoxy-tetrahydro-β-carboline (6MTHβC) has been synthesized and evaluated for its toxicity against the human neuroblastoma cell line (SK-N-SH) using the MTT assay. The assay was conducted at a concentration of 50 μM of each compound. The findings showed that four compounds exhibited toxicity toward SK-N-SH cells, while eight compounds demonstrated more than 50% cell viability. This study provides fundamental toxicological insights into these compounds and lays the groundwork for pharmacological and potential new treatment possibilities related to neurodegenerative disease. |
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