Unravelling the immunometabolic role of liver sinusoidal endothelial cells (LSECs) in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD)
Did you know that over 1 in 4 people worldwide may have fatty liver disease and most don’t even know it? Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver condition characterised by the accumulation of fat in the liver, accompanied by metabolic abnormalities such as obe...
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| Format: | Article |
| Language: | en |
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Faculty of Pharmacy
2025
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| Online Access: | https://ir.uitm.edu.my/id/eprint/120708/1/120708.pdf https://ir.uitm.edu.my/id/eprint/120708/ |
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| Summary: | Did you know that over 1 in 4 people worldwide may have fatty liver disease and most don’t even know it? Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver condition characterised by the accumulation of fat in the liver, accompanied by metabolic abnormalities such as obesity, insulin resistance (IR), type 2 diabetes, or metabolic dysregulation. MAFLD pathologies range from simple steatosis to a more severe inflammatory form known as metabolic dysfunction-associated steatohepatitis (MASH). MASH is marked by hepatocyte injury, fibrosis, and an increased risk of cirrhosis and hepatocellular carcinoma . Because MAFLD often presents with no symptoms in its early stages, many individuals remain unaware of the disease until significant liver damage has already occurred. |
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