Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman
Fluconazole is an antifungal agent used in the treatment of dermatophytes. The efficiency of the treatment depends on the rate of penetration of the drug into the skin. Topical preparations of fluconazole were prepared as ointment bases containing different penetration enhancers. The topical prepara...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | en |
| Published: |
2015
|
| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/117721/1/117721.PDF https://ir.uitm.edu.my/id/eprint/117721/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1836311263698747392 |
|---|---|
| author | Sulaiman, Mohamad Solihin |
| author_facet | Sulaiman, Mohamad Solihin |
| author_sort | Sulaiman, Mohamad Solihin |
| building | Tun Abdul Razak Library |
| collection | Institutional Repository |
| content_provider | Universiti Teknologi Mara |
| content_source | UiTM Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Fluconazole is an antifungal agent used in the treatment of dermatophytes. The efficiency of the treatment depends on the rate of penetration of the drug into the skin. Topical preparations of fluconazole were prepared as ointment bases containing different penetration enhancers. The topical preparations such as oleaginous base, absorption base, 0/W emulsion base, W /0 emulsion and water-soluble base were tested for their rheological properties and the in-vitro drug release from the formulation. The penetration enhancers tested were Dimethyl sulfoxide, Propanol and Oleic acid. The results show that water-soluble base containing propanol as the penetration enhancer has the highest release of fluconazole as compared with other formulations. The tested penetration enhancers could be arranged in the following descending order with respect to the amount of fluconazole released: Propanol > Dimethyl sulfoxide > Oleic acid |
| format | Thesis |
| id | my.uitm.ir-117721 |
| institution | Universiti Teknologi Mara |
| language | en |
| publishDate | 2015 |
| record_format | eprints |
| spelling | my.uitm.ir-1177212025-06-26T09:54:23Z https://ir.uitm.edu.my/id/eprint/117721/ Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman Sulaiman, Mohamad Solihin Drugs prescribing Antibacterial agents Fluconazole is an antifungal agent used in the treatment of dermatophytes. The efficiency of the treatment depends on the rate of penetration of the drug into the skin. Topical preparations of fluconazole were prepared as ointment bases containing different penetration enhancers. The topical preparations such as oleaginous base, absorption base, 0/W emulsion base, W /0 emulsion and water-soluble base were tested for their rheological properties and the in-vitro drug release from the formulation. The penetration enhancers tested were Dimethyl sulfoxide, Propanol and Oleic acid. The results show that water-soluble base containing propanol as the penetration enhancer has the highest release of fluconazole as compared with other formulations. The tested penetration enhancers could be arranged in the following descending order with respect to the amount of fluconazole released: Propanol > Dimethyl sulfoxide > Oleic acid 2015 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/117721/1/117721.PDF Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman. (2015) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam). |
| spellingShingle | Drugs prescribing Antibacterial agents Sulaiman, Mohamad Solihin Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title | Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title_full | Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title_fullStr | Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title_full_unstemmed | Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title_short | Use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / Mohamad Solihin Sulaiman |
| title_sort | use of penetration enhancers for increasing the in vitro release of fluconazole for topical application / mohamad solihin sulaiman |
| topic | Drugs prescribing Antibacterial agents |
| url | https://ir.uitm.edu.my/id/eprint/117721/1/117721.PDF https://ir.uitm.edu.my/id/eprint/117721/ |
| url_provider | http://ir.uitm.edu.my/ |