Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be...
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Elsevier Ltd
2006
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| Online Access: | http://eprints.sunway.edu.my/32/ http://dx.doi.org/10.1016/j.bmcl.2005.12.075 |
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| author | Tan, Siew Kiat * Pippen, Richard Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman, |
| author_facet | Tan, Siew Kiat * Pippen, Richard Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman, |
| author_sort | Tan, Siew Kiat * |
| building | Sunway Campus Library |
| collection | Institutional Repository |
| content_provider | Sunway University |
| content_source | Sunway Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. |
| format | Article |
| id | my.sunway.eprints.32 |
| institution | Sunway University |
| publishDate | 2006 |
| publisher | Elsevier Ltd |
| record_format | eprints |
| spelling | my.sunway.eprints.322018-01-30T02:42:45Z http://eprints.sunway.edu.my/32/ Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Tan, Siew Kiat * Pippen, Richard Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman, QK Botany RM Therapeutics. Pharmacology RS Pharmacy and materia medica Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. Elsevier Ltd 2006 Article PeerReviewed Tan, Siew Kiat * and Pippen, Richard and Rohana Yusof, and Halijah Ibrahim, and Norzulaani Khalid, and Noorsaadah Abd Rahman, (2006) Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorganic & Medicinal Chemistry Letters, 16 (12). pp. 3337-40. http://dx.doi.org/10.1016/j.bmcl.2005.12.075 |
| spellingShingle | QK Botany RM Therapeutics. Pharmacology RS Pharmacy and materia medica Tan, Siew Kiat * Pippen, Richard Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman, Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title | Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title_full | Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title_fullStr | Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title_full_unstemmed | Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title_short | Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. |
| title_sort | inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, boesenbergia rotunda (l.), towards dengue-2 virus ns3 protease. |
| topic | QK Botany RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | http://eprints.sunway.edu.my/32/ http://dx.doi.org/10.1016/j.bmcl.2005.12.075 |
| url_provider | http://eprints.sunway.edu.my/ |