Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis
Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the result...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
MDPI
2022
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/3103/ https://doi.org/10.3390/vaccines10081289 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1834424940553568256 |
|---|---|
| author | Alhumaid, Saad Rabaan, Ali A Dhama, Kuldeep Yong, Shin Jie * Nainu, Firzan Hajissa, Khalid Al Dossary, Nourah Alajmi, Khulood Khaled Al Saggar, Afaf E. AlHarbi, Fahad Abdullah Aswany, Mohammed Buhays Alsyhayee, Abdullah Abdulaziz Alrabiah, Saad Abdalaziz Saleh, Ahmed Mahmoud Alqarni, Mohammed Ali Al Gharib, Fahad Mohammed Qattan, Shahd Nabeel Almusabeh, Hassan M. AlGhatm, Hussain Yousef Almoraihel, Sameer Ahmed Alzuwaid, Ahmed Saeed Albaqshi, Mohammed Ali Al Khalaf, Murtadha Ahmed Albaqshi, Yasmine Ahmed Al Brahim, Abdulsatar H Al Mutared, Mahdi Mana Al-Helal, Hassan Alghazal, Header A Al Mutair, Abbas |
| author_facet | Alhumaid, Saad Rabaan, Ali A Dhama, Kuldeep Yong, Shin Jie * Nainu, Firzan Hajissa, Khalid Al Dossary, Nourah Alajmi, Khulood Khaled Al Saggar, Afaf E. AlHarbi, Fahad Abdullah Aswany, Mohammed Buhays Alsyhayee, Abdullah Abdulaziz Alrabiah, Saad Abdalaziz Saleh, Ahmed Mahmoud Alqarni, Mohammed Ali Al Gharib, Fahad Mohammed Qattan, Shahd Nabeel Almusabeh, Hassan M. AlGhatm, Hussain Yousef Almoraihel, Sameer Ahmed Alzuwaid, Ahmed Saeed Albaqshi, Mohammed Ali Al Khalaf, Murtadha Ahmed Albaqshi, Yasmine Ahmed Al Brahim, Abdulsatar H Al Mutared, Mahdi Mana Al-Helal, Hassan Alghazal, Header A Al Mutair, Abbas |
| author_sort | Alhumaid, Saad |
| building | Sunway Campus Library |
| collection | Institutional Repository |
| content_provider | Sunway University |
| content_source | Sunway Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the results of a systematic review for solid organ rejections following SARS-CoV-2 vaccination or COVID-19 infection. Methods: For this systematic review and meta-analysis, we searched Proquest, Medline, Embase, Pubmed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines for studies on the incidence of solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection, published from 1 December 2019 to 31 May 2022, with English language restriction. Results: One hundred thirty-six cases from fifty-two articles were included in the qualitative synthesis of this systematic review (56 solid organs rejected post-SARS-CoV-2 vaccination and 40 solid organs rejected following COVID-19 infection). Cornea rejection (44 cases) was the most frequent organ observed post-SARS-CoV-2 vaccination and following COVID-19 infection, followed by kidney rejection (36 cases), liver rejection (12 cases), lung rejection (2 cases), heart rejection (1 case) and pancreas rejection (1 case). The median or mean patient age ranged from 23 to 94 years across the studies. The majority of the patients were male (n = 51, 53.1%) and were of White (Caucasian) (n = 51, 53.7%) and Hispanic (n = 15, 15.8%) ethnicity. A total of fifty-six solid organ rejections were reported post-SARS-CoV-2 vaccination [Pfizer-BioNTech (n = 31), Moderna (n = 14), Oxford Uni-AstraZeneca (n = 10) and Sinovac-CoronaVac (n = 1)]. The median time from SARS-CoV-2 vaccination to organ rejection was 13.5 h (IQR, 3.2–17.2), while the median time from COVID-19 infection to organ rejection was 14 h (IQR, 5–21). Most patients were easily treated without any serious complications, recovered and did not require long-term allograft rejection therapy [graft success (n = 70, 85.4%), graft failure (n = 12, 14.6%), survived (n = 90, 95.7%) and died (n = 4, 4.3%)]. Conclusion: The reported evidence of solid organ rejections post-SARS-CoV-2 vaccination or COIVD-19 infection should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively small in relation to the hundreds of millions of vaccinations that have occurred, and the protective benefits offered by SARS-CoV-2 vaccination far outweigh the risks. |
| format | Article |
| id | my.sunway.eprints.3103 |
| institution | Sunway University |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | eprints |
| spelling | my.sunway.eprints.31032024-08-13T03:56:39Z http://eprints.sunway.edu.my/3103/ Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis Alhumaid, Saad Rabaan, Ali A Dhama, Kuldeep Yong, Shin Jie * Nainu, Firzan Hajissa, Khalid Al Dossary, Nourah Alajmi, Khulood Khaled Al Saggar, Afaf E. AlHarbi, Fahad Abdullah Aswany, Mohammed Buhays Alsyhayee, Abdullah Abdulaziz Alrabiah, Saad Abdalaziz Saleh, Ahmed Mahmoud Alqarni, Mohammed Ali Al Gharib, Fahad Mohammed Qattan, Shahd Nabeel Almusabeh, Hassan M. AlGhatm, Hussain Yousef Almoraihel, Sameer Ahmed Alzuwaid, Ahmed Saeed Albaqshi, Mohammed Ali Al Khalaf, Murtadha Ahmed Albaqshi, Yasmine Ahmed Al Brahim, Abdulsatar H Al Mutared, Mahdi Mana Al-Helal, Hassan Alghazal, Header A Al Mutair, Abbas QR Microbiology RB Pathology RM Therapeutics. Pharmacology Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the results of a systematic review for solid organ rejections following SARS-CoV-2 vaccination or COVID-19 infection. Methods: For this systematic review and meta-analysis, we searched Proquest, Medline, Embase, Pubmed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines for studies on the incidence of solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection, published from 1 December 2019 to 31 May 2022, with English language restriction. Results: One hundred thirty-six cases from fifty-two articles were included in the qualitative synthesis of this systematic review (56 solid organs rejected post-SARS-CoV-2 vaccination and 40 solid organs rejected following COVID-19 infection). Cornea rejection (44 cases) was the most frequent organ observed post-SARS-CoV-2 vaccination and following COVID-19 infection, followed by kidney rejection (36 cases), liver rejection (12 cases), lung rejection (2 cases), heart rejection (1 case) and pancreas rejection (1 case). The median or mean patient age ranged from 23 to 94 years across the studies. The majority of the patients were male (n = 51, 53.1%) and were of White (Caucasian) (n = 51, 53.7%) and Hispanic (n = 15, 15.8%) ethnicity. A total of fifty-six solid organ rejections were reported post-SARS-CoV-2 vaccination [Pfizer-BioNTech (n = 31), Moderna (n = 14), Oxford Uni-AstraZeneca (n = 10) and Sinovac-CoronaVac (n = 1)]. The median time from SARS-CoV-2 vaccination to organ rejection was 13.5 h (IQR, 3.2–17.2), while the median time from COVID-19 infection to organ rejection was 14 h (IQR, 5–21). Most patients were easily treated without any serious complications, recovered and did not require long-term allograft rejection therapy [graft success (n = 70, 85.4%), graft failure (n = 12, 14.6%), survived (n = 90, 95.7%) and died (n = 4, 4.3%)]. Conclusion: The reported evidence of solid organ rejections post-SARS-CoV-2 vaccination or COIVD-19 infection should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively small in relation to the hundreds of millions of vaccinations that have occurred, and the protective benefits offered by SARS-CoV-2 vaccination far outweigh the risks. MDPI 2022 Article PeerReviewed Alhumaid, Saad and Rabaan, Ali A and Dhama, Kuldeep and Yong, Shin Jie * and Nainu, Firzan and Hajissa, Khalid and Al Dossary, Nourah and Alajmi, Khulood Khaled and Al Saggar, Afaf E. and AlHarbi, Fahad Abdullah and Aswany, Mohammed Buhays and Alsyhayee, Abdullah Abdulaziz and Alrabiah, Saad Abdalaziz and Saleh, Ahmed Mahmoud and Alqarni, Mohammed Ali and Al Gharib, Fahad Mohammed and Qattan, Shahd Nabeel and Almusabeh, Hassan M. and AlGhatm, Hussain Yousef and Almoraihel, Sameer Ahmed and Alzuwaid, Ahmed Saeed and Albaqshi, Mohammed Ali and Al Khalaf, Murtadha Ahmed and Albaqshi, Yasmine Ahmed and Al Brahim, Abdulsatar H and Al Mutared, Mahdi Mana and Al-Helal, Hassan and Alghazal, Header A and Al Mutair, Abbas (2022) Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis. Vaccines, 10 (8). ISSN 2076-393X https://doi.org/10.3390/vaccines10081289 10.3390/vaccines10081289 |
| spellingShingle | QR Microbiology RB Pathology RM Therapeutics. Pharmacology Alhumaid, Saad Rabaan, Ali A Dhama, Kuldeep Yong, Shin Jie * Nainu, Firzan Hajissa, Khalid Al Dossary, Nourah Alajmi, Khulood Khaled Al Saggar, Afaf E. AlHarbi, Fahad Abdullah Aswany, Mohammed Buhays Alsyhayee, Abdullah Abdulaziz Alrabiah, Saad Abdalaziz Saleh, Ahmed Mahmoud Alqarni, Mohammed Ali Al Gharib, Fahad Mohammed Qattan, Shahd Nabeel Almusabeh, Hassan M. AlGhatm, Hussain Yousef Almoraihel, Sameer Ahmed Alzuwaid, Ahmed Saeed Albaqshi, Mohammed Ali Al Khalaf, Murtadha Ahmed Albaqshi, Yasmine Ahmed Al Brahim, Abdulsatar H Al Mutared, Mahdi Mana Al-Helal, Hassan Alghazal, Header A Al Mutair, Abbas Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title | Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title_full | Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title_fullStr | Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title_short | Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis |
| title_sort | solid organ rejection following sars-cov-2 vaccination or covid-19 infection: a systematic review and meta-analysis |
| topic | QR Microbiology RB Pathology RM Therapeutics. Pharmacology |
| url | http://eprints.sunway.edu.my/3103/ https://doi.org/10.3390/vaccines10081289 |
| url_provider | http://eprints.sunway.edu.my/ |