miRNA: A Promising Therapeutic Target in Cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR d...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
MDPI
2022
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| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/3078/1/Poh%20Chit%20Laa_miRNA%20a%20promising%20therapeutic%20target%20in%20cancer.pdf http://eprints.sunway.edu.my/3078/ https://doi.org/10.3390/ijms231911502 |
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| Summary: | microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy. |
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