Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy
Cancer is among the major leading causes of mortality globally, and chemotherapy is currently one of the most effective cancer therapies. Unfortunately, chemotherapy is invariably accompanied by dose-dependent cytotoxic side effects. Recently, genetically engineered adenoviruses emerged as an altern...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
W. S. Maney & Son
2022
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/3077/1/Tan%20Ee%20Wern_Engineered%20Oncolytic%20Adenoviruses.pdf http://eprints.sunway.edu.my/3077/ https://doi.org/10.3390/pathogens11101146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Cancer is among the major leading causes of mortality globally, and chemotherapy is currently one of the most effective cancer therapies. Unfortunately, chemotherapy is invariably accompanied by dose-dependent cytotoxic side effects. Recently, genetically engineered adenoviruses emerged as an alternative gene therapy approach targeting cancers. This review focuses on the characteristics of genetically modified adenovirus and oncology clinical studies using adenovirus-mediated gene therapy strategies. In addition, modulation of the tumor biology and the tumor microenvironment as well as the immunological responses associated with adenovirus-mediate cancer therapy are discussed. |
|---|