RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update
Colorectal cancer (CRC) remains among the most commonly diagnosed cancers and has been on the rise. It is also one of the most lethal diseases globally, being the third leading cause of cancerrelated death. Depending on the stages and disease conditions, CRC is treated by surgery, chemo-, radio-ther...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
College of Pathologists, Academy of Medicine Malaysia
2022
|
| Subjects: | |
| Online Access: | http://eprints.sunway.edu.my/3049/ https://www.mjpath.org.my/2022/v44n3/index.php |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1834424925855678464 |
|---|---|
| author | Ooi, Zhuan Shern * Pang, Siew Wai * Teow, Sin Yeang * |
| author_facet | Ooi, Zhuan Shern * Pang, Siew Wai * Teow, Sin Yeang * |
| author_sort | Ooi, Zhuan Shern * |
| building | Sunway Campus Library |
| collection | Institutional Repository |
| content_provider | Sunway University |
| content_source | Sunway Institutional Repository |
| continent | Asia |
| country | Malaysia |
| description | Colorectal cancer (CRC) remains among the most commonly diagnosed cancers and has been on the rise. It is also one of the most lethal diseases globally, being the third leading cause of cancerrelated death. Depending on the stages and disease conditions, CRC is treated by surgery, chemo-, radio-therapy, immunotherapy or in combination. However, these therapies have subpar results with unwanted side effects, hence continuous effort is ongoing to explore new type of therapeutic modalities. Among the sub-types of CRC, KRAS, BRAF and NRAS mutated CRC comprise approximately 43%, 10% and 3% of the total cases, respectively. These mutations are associated with tumour progression and anti-epidermal growth factor receptor (EGFR) treatment resistance. Due to their important role in CRC, these genes have thus become targets in the development of novel treatments. In this paper, we discuss the current and upcoming treatment on CRC by targeting these mutated genes, with more focus on KRAS and BRAF due to the higher occurrence of mutations in CRC. |
| format | Article |
| id | my.sunway.eprints.3049 |
| institution | Sunway University |
| publishDate | 2022 |
| publisher | College of Pathologists, Academy of Medicine Malaysia |
| record_format | eprints |
| spelling | my.sunway.eprints.30492024-08-10T04:43:28Z http://eprints.sunway.edu.my/3049/ RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update Ooi, Zhuan Shern * Pang, Siew Wai * Teow, Sin Yeang * QH Natural history R Medicine (General) RC Internal medicine Colorectal cancer (CRC) remains among the most commonly diagnosed cancers and has been on the rise. It is also one of the most lethal diseases globally, being the third leading cause of cancerrelated death. Depending on the stages and disease conditions, CRC is treated by surgery, chemo-, radio-therapy, immunotherapy or in combination. However, these therapies have subpar results with unwanted side effects, hence continuous effort is ongoing to explore new type of therapeutic modalities. Among the sub-types of CRC, KRAS, BRAF and NRAS mutated CRC comprise approximately 43%, 10% and 3% of the total cases, respectively. These mutations are associated with tumour progression and anti-epidermal growth factor receptor (EGFR) treatment resistance. Due to their important role in CRC, these genes have thus become targets in the development of novel treatments. In this paper, we discuss the current and upcoming treatment on CRC by targeting these mutated genes, with more focus on KRAS and BRAF due to the higher occurrence of mutations in CRC. College of Pathologists, Academy of Medicine Malaysia 2022 Article PeerReviewed Ooi, Zhuan Shern * and Pang, Siew Wai * and Teow, Sin Yeang * (2022) RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update. The Malaysian Journal of Pathology, 44 (3). pp. 415-428. ISSN 0126-8635 https://www.mjpath.org.my/2022/v44n3/index.php |
| spellingShingle | QH Natural history R Medicine (General) RC Internal medicine Ooi, Zhuan Shern * Pang, Siew Wai * Teow, Sin Yeang * RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title | RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title_full | RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title_fullStr | RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title_full_unstemmed | RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title_short | RAS and BRAF genes as biomarkers and target for personalised colorectal cancer therapy: An update |
| title_sort | ras and braf genes as biomarkers and target for personalised colorectal cancer therapy: an update |
| topic | QH Natural history R Medicine (General) RC Internal medicine |
| url | http://eprints.sunway.edu.my/3049/ https://www.mjpath.org.my/2022/v44n3/index.php |
| url_provider | http://eprints.sunway.edu.my/ |