Mechanical properties and in vitro evaluation of thermoplastic polyurethane and polylactic acid blend for fabrication of 3D filaments for tracheal tissue engineering
Surgical reconstruction of extensive tracheal lesions is challenging. It requires a mechanically stable, biocompatible, and nontoxic material that gradually degrades. One of the possible solutions for overcoming the limitations of tracheal transplantation is a three-dimensional (3D) printed trach...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | en en en |
| Published: |
MDPI
2021
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/96297/1/96297_Mechanical%20properties%20and%20in%20vitro%20evaluation.pdf http://irep.iium.edu.my/96297/2/96297_Mechanical%20properties%20and%20in%20vitro%20evaluation_SCOPUS.pdf http://irep.iium.edu.my/96297/3/96297_Mechanical%20properties%20and%20in%20vitro%20evaluation_WoS.pdf http://irep.iium.edu.my/96297/ https://www.mdpi.com/journal/polymers |
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| Summary: | Surgical reconstruction of extensive tracheal lesions is challenging. It requires a mechanically
stable, biocompatible, and nontoxic material that gradually degrades. One of the possible
solutions for overcoming the limitations of tracheal transplantation is a three-dimensional (3D)
printed tracheal scaffold made of polymers. Polymer blending is one of the methods used to produce
material for a trachea scaffold with tailored characteristics. The purpose of this study is to evaluate
the mechanical and in vitro properties of a thermoplastic polyurethane (TPU) and polylactic acid
(PLA) blend as a potential material for 3D printed tracheal scaffolds. Both materials were meltblended
using a single screw extruder. The morphologies (as well as the mechanical and thermal
characteristics) were determined via scanning electron microscopy (SEM), Fourier Transform Infrared
(FTIR) spectroscopy, tensile test, and Differential Scanning calorimetry (DSC). The samples
were also evaluated for their water absorption, in vitro biodegradability, and biocompatibility. It is
demonstrated that, despite being not miscible, TPU and PLA are biocompatible, and their promising
properties are suitable for future applications in tracheal tissue engineering. |
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