Metformin therapy attenuates pro-inflammatory Microglia by inhibiting NF-κB in cuprizone demyelinating mouse model of multiple Sclerosis

Multiple sclerosis (MS) is a chronic disorder characterized by reactive gliosis, inflammation, and demyelination. Microglia plays a crucial role in the pathogenesis of MS and has the dynamic plasticity to polarize between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. Metformin, a gluc...

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Main Authors:	Abdi, Mahdad, Pasbakhsh, Parichehr, Shabani, Maryam, Nekoonam, Saied, Sadeghi, Asie, Fathi, Fardin, Abouzaripour, Morteza, Mohamed, Wael Mohamed Yousef, Zibara, Kazem, Kashani, Iraj Ragerdi, Zendedel, Adib
Format:	Article
Language:	en en
Published:	Springer 2021
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/94204/7/94202_Metformin%20therapy%20attenuates%20pro-inflammatory_SCOPUS.pdf http://irep.iium.edu.my/94204/8/94202_Metformin%20therapy%20attenuates%20pro-inflammatory.pdf http://irep.iium.edu.my/94204/ https://link.springer.com/article/10.1007%2Fs12640-021-00417-y#ethics
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